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Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains.
Boija A, Klein IA, Sabari BR, Dall'Agnese A, Coffey EL, Zamudio AV, Li CH, Shrinivas K, Manteiga JC, Hannett NM, Abraham BJ, Afeyan LK, Guo YE, Rimel JK, Fant CB, Schuijers J, Lee TI, Taatjes DJ, Young RA. Boija A, et al. Among authors: fant cb. Cell. 2018 Dec 13;175(7):1842-1855.e16. doi: 10.1016/j.cell.2018.10.042. Epub 2018 Nov 15. Cell. 2018. PMID: 30449618 Free PMC article.
Pol II phosphorylation regulates a switch between transcriptional and splicing condensates.
Guo YE, Manteiga JC, Henninger JE, Sabari BR, Dall'Agnese A, Hannett NM, Spille JH, Afeyan LK, Zamudio AV, Shrinivas K, Abraham BJ, Boija A, Decker TM, Rimel JK, Fant CB, Lee TI, Cisse II, Sharp PA, Taatjes DJ, Young RA. Guo YE, et al. Among authors: fant cb. Nature. 2019 Aug;572(7770):543-548. doi: 10.1038/s41586-019-1464-0. Epub 2019 Aug 7. Nature. 2019. PMID: 31391587 Free PMC article.
TFIID Enables RNA Polymerase II Promoter-Proximal Pausing.
Fant CB, Levandowski CB, Gupta K, Maas ZL, Moir J, Rubin JD, Sawyer A, Esbin MN, Rimel JK, Luyties O, Marr MT, Berger I, Dowell RD, Taatjes DJ. Fant CB, et al. Mol Cell. 2020 May 21;78(4):785-793.e8. doi: 10.1016/j.molcel.2020.03.008. Epub 2020 Mar 30. Mol Cell. 2020. PMID: 32229306 Free PMC article.