Farady CJ - Search Results

1

Coordinate expression and functional profiling identify an extracellular proteolytic signaling pathway.

Bhatt AS, Welm A, Farady CJ, Vásquez M, Wilson K, Craik CS. Bhatt AS, et al. Among authors: farady cj. Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):5771-6. doi: 10.1073/pnas.0606514104. Epub 2007 Mar 27. Proc Natl Acad Sci U S A. 2007. PMID: 17389401 Free PMC article.

2

The mechanism of inhibition of antibody-based inhibitors of membrane-type serine protease 1 (MT-SP1).

Farady CJ, Sun J, Darragh MR, Miller SM, Craik CS. Farady CJ, et al. J Mol Biol. 2007 Jun 15;369(4):1041-51. doi: 10.1016/j.jmb.2007.03.078. Epub 2007 Apr 4. J Mol Biol. 2007. PMID: 17475279 Free PMC article.

3

Structure of an Fab-protease complex reveals a highly specific non-canonical mechanism of inhibition.

Farady CJ, Egea PF, Schneider EL, Darragh MR, Craik CS. Farady CJ, et al. J Mol Biol. 2008 Jul 4;380(2):351-60. doi: 10.1016/j.jmb.2008.05.009. Epub 2008 May 11. J Mol Biol. 2008. PMID: 18514224 Free PMC article.

4

Improving the species cross-reactivity of an antibody using computational design.

Farady CJ, Sellers BD, Jacobson MP, Craik CS. Farady CJ, et al. Bioorg Med Chem Lett. 2009 Jul 15;19(14):3744-7. doi: 10.1016/j.bmcl.2009.05.005. Epub 2009 May 7. Bioorg Med Chem Lett. 2009. PMID: 19477127 Free PMC article.

5

Tumor detection by imaging proteolytic activity.

Darragh MR, Schneider EL, Lou J, Phojanakong PJ, Farady CJ, Marks JD, Hann BC, Craik CS. Darragh MR, et al. Among authors: farady cj. Cancer Res. 2010 Feb 15;70(4):1505-12. doi: 10.1158/0008-5472.CAN-09-1640. Epub 2010 Feb 9. Cancer Res. 2010. PMID: 20145119 Free PMC article.

6

Mechanisms of macromolecular protease inhibitors.

Farady CJ, Craik CS. Farady CJ, et al. Chembiochem. 2010 Nov 22;11(17):2341-6. doi: 10.1002/cbic.201000442. Chembiochem. 2010. PMID: 21053238 Free PMC article. Review. No abstract available.

7

A reverse binding motif that contributes to specific protease inhibition by antibodies.

Schneider EL, Lee MS, Baharuddin A, Goetz DH, Farady CJ, Ward M, Wang CI, Craik CS. Schneider EL, et al. Among authors: farady cj. J Mol Biol. 2012 Jan 27;415(4):699-715. doi: 10.1016/j.jmb.2011.11.036. Epub 2011 Nov 27. J Mol Biol. 2012. PMID: 22154938 Free PMC article.

8

Vinyl sulfones as antiparasitic agents and a structural basis for drug design.

Kerr ID, Lee JH, Farady CJ, Marion R, Rickert M, Sajid M, Pandey KC, Caffrey CR, Legac J, Hansell E, McKerrow JH, Craik CS, Rosenthal PJ, Brinen LS. Kerr ID, et al. Among authors: farady cj. J Biol Chem. 2009 Sep 18;284(38):25697-703. doi: 10.1074/jbc.M109.014340. Epub 2009 Jul 20. J Biol Chem. 2009. PMID: 19620707 Free PMC article.

9

Fragment-Based Protein-Protein Interaction Antagonists of a Viral Dimeric Protease.

Gable JE, Lee GM, Acker TM, Hulce KR, Gonzalez ER, Schweigler P, Melkko S, Farady CJ, Craik CS. Gable JE, et al. Among authors: farady cj. ChemMedChem. 2016 Apr 19;11(8):862-9. doi: 10.1002/cmdc.201500526. Epub 2016 Jan 28. ChemMedChem. 2016. PMID: 26822284 Free PMC article.

10

Crystal Structure of NLRP3 NACHT Domain With an Inhibitor Defines Mechanism of Inflammasome Inhibition.

Dekker C, Mattes H, Wright M, Boettcher A, Hinniger A, Hughes N, Kapps-Fouthier S, Eder J, Erbel P, Stiefl N, Mackay A, Farady CJ. Dekker C, et al. Among authors: farady cj. J Mol Biol. 2021 Dec 3;433(24):167309. doi: 10.1016/j.jmb.2021.167309. Epub 2021 Oct 20. J Mol Biol. 2021. PMID: 34687713

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