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Page 1
Immunoproteasome deficiency results in age-dependent development of epilepsy.
Leister H, Krause FF, Gil B, Prus R, Prus I, Hellhund-Zingel A, Mitra M, Da Rosa Gerbatin R, Delanty N, Beausang A, Brett FM, Farrell MA, Cryan J, O'Brien DF, Henshall DC, Helmprobst F, Pagenstecher A, Steinhoff U, Visekruna A, Engel T. Leister H, et al. Among authors: farrell ma. Brain Commun. 2024 Jan 29;6(1):fcae017. doi: 10.1093/braincomms/fcae017. eCollection 2024. Brain Commun. 2024. PMID: 38317856 Free PMC article.
CHOP regulates the p53-MDM2 axis and is required for neuronal survival after seizures.
Engel T, Sanz-Rodgriguez A, Jimenez-Mateos EM, Concannon CG, Jimenez-Pacheco A, Moran C, Mesuret G, Petit E, Delanty N, Farrell MA, O'Brien DF, Prehn JH, Lucas JJ, Henshall DC. Engel T, et al. Among authors: farrell ma. Brain. 2013 Feb;136(Pt 2):577-92. doi: 10.1093/brain/aws337. Epub 2013 Jan 29. Brain. 2013. PMID: 23361066
Microvascular stabilization via blood-brain barrier regulation prevents seizure activity.
Greene C, Hanley N, Reschke CR, Reddy A, Mäe MA, Connolly R, Behan C, O'Keeffe E, Bolger I, Hudson N, Delaney C, Farrell MA, O'Brien DF, Cryan J, Brett FM, Beausang A, Betsholtz C, Henshall DC, Doherty CP, Campbell M. Greene C, et al. Among authors: farrell ma. Nat Commun. 2022 Apr 14;13(1):2003. doi: 10.1038/s41467-022-29657-y. Nat Commun. 2022. PMID: 35422069 Free PMC article.
CPEB4-CLOCK crosstalk during temporal lobe epilepsy.
de Diego-Garcia L, Brennan GP, Auer T, Menendez-Mendez A, Parras A, Martin-Gil A, Mitra M, Ollà I, Villalba-Benito L, Gil B, Alves M, Lau K, Delanty N, Beausang A, Cryan J, Brett FM, Farrell MA, O'Brien DF, Mendez R, Carracedo-Rodríguez G, Henshall DC, Lucas JJ, Engel T. de Diego-Garcia L, et al. Among authors: farrell ma. Epilepsia. 2023 Oct;64(10):2827-2840. doi: 10.1111/epi.17736. Epub 2023 Aug 14. Epilepsia. 2023. PMID: 37543852
Transient P2X7 Receptor Antagonism Produces Lasting Reductions in Spontaneous Seizures and Gliosis in Experimental Temporal Lobe Epilepsy.
Jimenez-Pacheco A, Diaz-Hernandez M, Arribas-Blázquez M, Sanz-Rodriguez A, Olivos-Oré LA, Artalejo AR, Alves M, Letavic M, Miras-Portugal MT, Conroy RM, Delanty N, Farrell MA, O'Brien DF, Bhattacharya A, Engel T, Henshall DC. Jimenez-Pacheco A, et al. Among authors: farrell ma. J Neurosci. 2016 Jun 1;36(22):5920-32. doi: 10.1523/JNEUROSCI.4009-15.2016. J Neurosci. 2016. PMID: 27251615 Free PMC article.
Potent Anti-seizure Effects of Locked Nucleic Acid Antagomirs Targeting miR-134 in Multiple Mouse and Rat Models of Epilepsy.
Reschke CR, Silva LFA, Norwood BA, Senthilkumar K, Morris G, Sanz-Rodriguez A, Conroy RM, Costard L, Neubert V, Bauer S, Farrell MA, O'Brien DF, Delanty N, Schorge S, Pasterkamp RJ, Rosenow F, Henshall DC. Reschke CR, et al. Among authors: farrell ma. Mol Ther Nucleic Acids. 2017 Mar 17;6:45-56. doi: 10.1016/j.omtn.2016.11.002. Epub 2016 Dec 10. Mol Ther Nucleic Acids. 2017. PMID: 28325299 Free PMC article.
Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects.
Jimenez-Mateos EM, Engel T, Merino-Serrais P, McKiernan RC, Tanaka K, Mouri G, Sano T, O'Tuathaigh C, Waddington JL, Prenter S, Delanty N, Farrell MA, O'Brien DF, Conroy RM, Stallings RL, DeFelipe J, Henshall DC. Jimenez-Mateos EM, et al. Among authors: farrell ma. Nat Med. 2012 Jul;18(7):1087-94. doi: 10.1038/nm.2834. Nat Med. 2012. PMID: 22683779 Free PMC article.
181 results