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Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species.
Qian L, Wythe JD, Liu J, Cartry J, Vogler G, Mohapatra B, Otway RT, Huang Y, King IN, Maillet M, Zheng Y, Crawley T, Taghli-Lamallem O, Semsarian C, Dunwoodie S, Winlaw D, Harvey RP, Fatkin D, Towbin JA, Molkentin JD, Srivastava D, Ocorr K, Bruneau BG, Bodmer R. Qian L, et al. Among authors: fatkin d. J Cell Biol. 2011 Jun 27;193(7):1181-96. doi: 10.1083/jcb.201006114. Epub 2011 Jun 20. J Cell Biol. 2011. PMID: 21690310 Free PMC article.
Cardiomyopathy in Irx4-deficient mice is preceded by abnormal ventricular gene expression.
Bruneau BG, Bao ZZ, Fatkin D, Xavier-Neto J, Georgakopoulos D, Maguire CT, Berul CI, Kass DA, Kuroski-de Bold ML, de Bold AJ, Conner DA, Rosenthal N, Cepko CL, Seidman CE, Seidman JG. Bruneau BG, et al. Among authors: fatkin d. Mol Cell Biol. 2001 Mar;21(5):1730-6. doi: 10.1128/MCB.21.5.1730-1736.2001. Mol Cell Biol. 2001. PMID: 11238910 Free PMC article.
Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptation.
Stennard FA, Costa MW, Lai D, Biben C, Furtado MB, Solloway MJ, McCulley DJ, Leimena C, Preis JI, Dunwoodie SL, Elliott DE, Prall OW, Black BL, Fatkin D, Harvey RP. Stennard FA, et al. Among authors: fatkin d. Development. 2005 May;132(10):2451-62. doi: 10.1242/dev.01799. Epub 2005 Apr 20. Development. 2005. PMID: 15843414
Mutations in cardiac T-box factor gene TBX20 are associated with diverse cardiac pathologies, including defects of septation and valvulogenesis and cardiomyopathy.
Kirk EP, Sunde M, Costa MW, Rankin SA, Wolstein O, Castro ML, Butler TL, Hyun C, Guo G, Otway R, Mackay JP, Waddell LB, Cole AD, Hayward C, Keogh A, Macdonald P, Griffiths L, Fatkin D, Sholler GF, Zorn AM, Feneley MP, Winlaw DS, Harvey RP. Kirk EP, et al. Among authors: fatkin d. Am J Hum Genet. 2007 Aug;81(2):280-91. doi: 10.1086/519530. Epub 2007 Jun 15. Am J Hum Genet. 2007. PMID: 17668378 Free PMC article.
Atrial fibrillation--a new cardiac channelopathy.
Otway R, Vandenberg JI, Fatkin D. Otway R, et al. Among authors: fatkin d. Heart Lung Circ. 2007 Oct;16(5):356-60. doi: 10.1016/j.hlc.2007.07.003. Epub 2007 Sep 4. Heart Lung Circ. 2007. PMID: 17768091 Review.
Genetics of dilated cardiomyopathy.
Fatkin D, Otway R, Richmond Z. Fatkin D, et al. Heart Fail Clin. 2010 Apr;6(2):129-40. doi: 10.1016/j.hfc.2009.11.003. Heart Fail Clin. 2010. PMID: 20347783 Review.
167 results