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2020 2
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Page 1
SUMO pathway inhibition targets an aggressive pancreatic cancer subtype.
Biederstädt A, Hassan Z, Schneeweis C, Schick M, Schneider L, Muckenhuber A, Hong Y, Siegers G, Nilsson L, Wirth M, Dantes Z, Steiger K, Schunck K, Langston S, Lenhof HP, Coluccio A, Orben F, Slawska J, Scherger A, Saur D, Müller S, Rad R, Weichert W, Nilsson J, Reichert M, Schneider G, Keller U. Biederstädt A, et al. Among authors: orben f. Gut. 2020 Aug;69(8):1472-1482. doi: 10.1136/gutjnl-2018-317856. Epub 2020 Jan 30. Gut. 2020. PMID: 32001555 Free PMC article.
Epigenetic drug screening defines a PRMT5 inhibitor-sensitive pancreatic cancer subtype.
Orben F, Lankes K, Schneeweis C, Hassan Z, Jakubowsky H, Krauß L, Boniolo F, Schneider C, Schäfer A, Murr J, Schlag C, Kong B, Öllinger R, Wang C, Beyer G, Mahajan UM, Xue Y, Mayerle J, Schmid RM, Kuster B, Rad R, Braun CJ, Wirth M, Reichert M, Saur D, Schneider G. Orben F, et al. JCI Insight. 2022 May 23;7(10):e151353. doi: 10.1172/jci.insight.151353. JCI Insight. 2022. PMID: 35439169 Free PMC article.
Human JAK1 gain of function causes dysregulated myelopoeisis and severe allergic inflammation.
Biggs CM, Cordeiro-Santanach A, Prykhozhij SV, Deveau AP, Lin Y, Del Bel KL, Orben F, Ragotte RJ, Saferali A, Mostafavi S, Dinh L, Dai D, Weinacht KG, Dobbs K, Ott de Bruin L, Sharma M, Tsai K, Priatel JJ, Schreiber RA, Rozmus J, Hosking MC, Shopsowitz KE, McKinnon ML, Vercauteren S, Seear M, Notarangelo LD, Lynn FC, Berman JN, Turvey SE. Biggs CM, et al. Among authors: orben f. JCI Insight. 2022 Dec 22;7(24):e150849. doi: 10.1172/jci.insight.150849. JCI Insight. 2022. PMID: 36546480 Free PMC article.
Identification of treatment-induced vulnerabilities in pancreatic cancer patients using functional model systems.
Peschke K, Jakubowsky H, Schäfer A, Maurer C, Lange S, Orben F, Bernad R, Harder FN, Eiber M, Öllinger R, Steiger K, Schlitter M, Weichert W, Mayr U, Phillip V, Schlag C, Schmid RM, Braren RF, Kong B, Demir IE, Friess H, Rad R, Saur D, Schneider G, Reichert M. Peschke K, et al. Among authors: orben f. EMBO Mol Med. 2022 Apr 7;14(4):e14876. doi: 10.15252/emmm.202114876. Epub 2022 Feb 4. EMBO Mol Med. 2022. PMID: 35119792 Free PMC article.
A novel Cereblon E3 ligase modulator with antitumor activity in gastrointestinal cancer.
Lier S, Sellmer A, Orben F, Heinzlmeir S, Krauß L, Schneeweis C, Hassan Z, Schneider C, Patricia Gloria Schäfer A, Pongratz H, Engleitner T, Öllinger R, Kuisl A, Bassermann F, Schlag C, Kong B, Dove S, Kuster B, Rad R, Reichert M, Wirth M, Saur D, Mahboobi S, Schneider G. Lier S, et al. Among authors: orben f. Bioorg Chem. 2022 Feb;119:105505. doi: 10.1016/j.bioorg.2021.105505. Epub 2021 Nov 20. Bioorg Chem. 2022. PMID: 34838332 Free article.
NOXA expression drives synthetic lethality to RUNX1 inhibition in pancreatic cancer.
Doffo J, Bamopoulos SA, Köse H, Orben F, Zang C, Pons M, den Dekker AT, Brouwer RWW, Baluapuri A, Habringer S, Reichert M, Illendula A, Krämer OH, Schick M, Wolf E, van IJcken WFJ, Esposito I, Keller U, Schneider G, Wirth M. Doffo J, et al. Among authors: orben f. Proc Natl Acad Sci U S A. 2022 Mar 1;119(9):e2105691119. doi: 10.1073/pnas.2105691119. Proc Natl Acad Sci U S A. 2022. PMID: 35197278 Free PMC article.
Indirect targeting of MYC sensitizes pancreatic cancer cells to mechanistic target of rapamycin (mTOR) inhibition.
Schneeweis C, Hassan Z, Ascherl K, Wirth M, Koutsouli S, Orben F, Krauß L, Schneider C, Öllinger R, Krämer OH, Rad R, Reichert M, Robles MS, Saur D, Schneider G. Schneeweis C, et al. Among authors: orben f. Cancer Commun (Lond). 2022 Apr;42(4):360-364. doi: 10.1002/cac2.12280. Epub 2022 Mar 7. Cancer Commun (Lond). 2022. PMID: 35253411 Free PMC article. No abstract available.
Implementing cell-free DNA of pancreatic cancer patient-derived organoids for personalized oncology.
Dantes Z, Yen HY, Pfarr N, Winter C, Steiger K, Muckenhuber A, Hennig A, Lange S, Engleitner T, Öllinger R, Maresch R, Orben F, Heid I, Kaissis G, Shi K, Topping G, Stögbauer F, Wirth M, Peschke K, Papargyriou A, Rezaee-Oghazi M, Feldmann K, Schäfer AP, Ranjan R, Lubeseder-Martellato C, Stange DE, Welsch T, Martignoni M, Ceyhan GO, Friess H, Herner A, Liotta L, Treiber M, von Figura G, Abdelhafez M, Klare P, Schlag C, Algül H, Siveke J, Braren R, Weirich G, Weichert W, Saur D, Rad R, Schmid RM, Schneider G, Reichert M. Dantes Z, et al. Among authors: orben f. JCI Insight. 2020 Aug 6;5(15):e137809. doi: 10.1172/jci.insight.137809. JCI Insight. 2020. PMID: 32614802 Free PMC article.
Comparison of endoscopic ultrasound-guided fine-needle aspiration and fine-needle biopsy to generate pancreatic cancer organoids: Randomized trial.
Wiessner JR, Orben F, Schäfer A, Fricke L, Schneider G, Reichert M, Herner A, Mayr U, Phillip V, Treiber M, von Figura G, Abdelhafez M, Schmid RM, Schlag C. Wiessner JR, et al. Among authors: orben f. Endosc Int Open. 2024 Mar 7;12(3):E361-E366. doi: 10.1055/a-2257-3171. eCollection 2024 Mar. Endosc Int Open. 2024. PMID: 38464982 Free PMC article.
Corrigendum to "A novel Cereblon E3 ligase modulator with antitumor activity in gastrointestinal cancer" [Bioorgan. Chem. 119 (2022) 105505].
Lier S, Sellmer A, Orben F, Heinzlmeir S, Krauß L, Schneeweis C, Hassan Z, Schneider C, Schäfer A, Pongratz H, Engleitner T, Öllinger R, Kuisl A, Bassermann F, Schlag C, Kong B, Dove S, Kuster B, Rad R, Reichert M, Wirth M, Saur D, Mahboobi S, Schneider G. Lier S, et al. Among authors: orben f. Bioorg Chem. 2024 May;146:107248. doi: 10.1016/j.bioorg.2024.107248. Epub 2024 Mar 7. Bioorg Chem. 2024. PMID: 38458892 No abstract available.