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Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNA.
Melero R, Rajagopalan S, Lázaro M, Joerger AC, Brandt T, Veprintsev DB, Lasso G, Gil D, Scheres SH, Carazo JM, Fersht AR, Valle M. Melero R, et al. Among authors: fersht ar. Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):557-62. doi: 10.1073/pnas.1015520107. Epub 2010 Dec 22. Proc Natl Acad Sci U S A. 2011. PMID: 21178074 Free PMC article.
Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex.
Tidow H, Melero R, Mylonas E, Freund SM, Grossmann JG, Carazo JM, Svergun DI, Valle M, Fersht AR. Tidow H, et al. Among authors: fersht ar. Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12324-9. doi: 10.1073/pnas.0705069104. Epub 2007 Jul 9. Proc Natl Acad Sci U S A. 2007. PMID: 17620598 Free PMC article.
Cooperative binding of tetrameric p53 to DNA.
Weinberg RL, Veprintsev DB, Fersht AR. Weinberg RL, et al. Among authors: fersht ar. J Mol Biol. 2004 Aug 27;341(5):1145-59. doi: 10.1016/j.jmb.2004.06.071. J Mol Biol. 2004. PMID: 15321712
Regulation of DNA binding of p53 by its C-terminal domain.
Weinberg RL, Freund SM, Veprintsev DB, Bycroft M, Fersht AR. Weinberg RL, et al. Among authors: fersht ar. J Mol Biol. 2004 Sep 17;342(3):801-11. doi: 10.1016/j.jmb.2004.07.042. J Mol Biol. 2004. PMID: 15342238
The central region of HDM2 provides a second binding site for p53.
Yu GW, Rudiger S, Veprintsev D, Freund S, Fernandez-Fernandez MR, Fersht AR. Yu GW, et al. Among authors: fersht ar. Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1227-32. doi: 10.1073/pnas.0510343103. Epub 2006 Jan 23. Proc Natl Acad Sci U S A. 2006. PMID: 16432196 Free PMC article.
Core domain interactions in full-length p53 in solution.
Veprintsev DB, Freund SM, Andreeva A, Rutledge SE, Tidow H, Cañadillas JM, Blair CM, Fersht AR. Veprintsev DB, et al. Among authors: fersht ar. Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2115-9. doi: 10.1073/pnas.0511130103. Epub 2006 Feb 6. Proc Natl Acad Sci U S A. 2006. PMID: 16461914 Free PMC article.
537 results