Fesik SW - Search Results

1

Discovery of Potent 2-Aryl-6,7-dihydro-5 H-pyrrolo[1,2- a]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design.

Wang F, Jeon KO, Salovich JM, Macdonald JD, Alvarado J, Gogliotti RD, Phan J, Olejniczak ET, Sun Q, Wang S, Camper D, Yuh JP, Shaw JG, Sai J, Rossanese OW, Tansey WP, Stauffer SR, Fesik SW. Wang F, et al. Among authors: fesik sw. J Med Chem. 2018 Jul 12;61(13):5623-5642. doi: 10.1021/acs.jmedchem.8b00375. Epub 2018 Jun 29. J Med Chem. 2018. PMID: 29889518 Free PMC article.

2

A 4D HCCH-TOCSY experiment for assigning the side chain 1H and 13C resonances of proteins.

Olejniczak ET, Xu RX, Fesik SW. Olejniczak ET, et al. Among authors: fesik sw. J Biomol NMR. 1992 Nov;2(6):655-9. doi: 10.1007/BF02192854. J Biomol NMR. 1992. PMID: 1283353

3

Stereospecific assignments and chi 1 rotamers for FKBP when bound to ascomycin from 3JH alpha,H beta and 3HN,H beta coupling constants.

Xu RX, Olejniczak ET, Fesik SW. Xu RX, et al. Among authors: fesik sw. FEBS Lett. 1992 Jun 29;305(2):137-43. doi: 10.1016/0014-5793(92)80881-g. FEBS Lett. 1992. PMID: 1377648 Free article.

4

NMR studies of an FK-506 analog, [U-13C]ascomycin, bound to FK-506-binding protein.

Petros AM, Gemmecker G, Neri P, Olejniczak ET, Nettesheim D, Xu RX, Gubbins EG, Smith H, Fesik SW. Petros AM, et al. Among authors: fesik sw. J Med Chem. 1992 Jun 26;35(13):2467-73. doi: 10.1021/jm00091a015. J Med Chem. 1992. PMID: 1377749

5

NMR methods for determining the structures of enzyme/inhibitor complexes as an aid in drug design.

Fesik SW, Zuiderweg ER, Olejniczak ET, Gampe RT Jr. Fesik SW, et al. Biochem Pharmacol. 1990 Jul 1;40(1):161-7. doi: 10.1016/0006-2952(90)90191-m. Biochem Pharmacol. 1990. PMID: 2115336 Review.

6

A computer-based protocol for semiautomated assignments and 3D structure determination of proteins.

Meadows RP, Olejniczak ET, Fesik SW. Meadows RP, et al. Among authors: fesik sw. J Biomol NMR. 1994 Jan;4(1):79-96. doi: 10.1007/BF00178337. J Biomol NMR. 1994. PMID: 7510556

7

NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain.

Huang B, Eberstadt M, Olejniczak ET, Meadows RP, Fesik SW. Huang B, et al. Among authors: fesik sw. Nature. 1996 Dec 19-26;384(6610):638-41. doi: 10.1038/384638a0. Nature. 1996. PMID: 8967952

8

Changes in the NMR-derived motional parameters of the insulin receptor substrate 1 phosphotyrosine binding domain upon binding to an interleukin 4 receptor phosphopeptide.

Olejniczak ET, Zhou MM, Fesik SW. Olejniczak ET, et al. Among authors: fesik sw. Biochemistry. 1997 Apr 8;36(14):4118-24. doi: 10.1021/bi963050i. Biochemistry. 1997. PMID: 9100005

9

NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein.

Hajduk PJ, Dinges J, Miknis GF, Merlock M, Middleton T, Kempf DJ, Egan DA, Walter KA, Robins TS, Shuker SB, Holzman TF, Fesik SW. Hajduk PJ, et al. Among authors: fesik sw. J Med Chem. 1997 Sep 26;40(20):3144-50. doi: 10.1021/jm9703404. J Med Chem. 1997. PMID: 9379433

10

Design of adenosine kinase inhibitors from the NMR-based screening of fragments.

Hajduk PJ, Gomtsyan A, Didomenico S, Cowart M, Bayburt EK, Solomon L, Severin J, Smith R, Walter K, Holzman TF, Stewart A, McGaraughty S, Jarvis MF, Kowaluk EA, Fesik SW. Hajduk PJ, et al. Among authors: fesik sw. J Med Chem. 2000 Dec 14;43(25):4781-6. doi: 10.1021/jm000373a. J Med Chem. 2000. PMID: 11123986

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