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Catalytic Degraders Effectively Address Kinase Site Mutations in EML4-ALK Oncogenic Fusions.
Gao Y, Jiang B, Kim H, Berberich MJ, Che J, Donovan KA, Hatcher JM, Huerta F, Kwiatkowski NP, Liu Y, Liuni PP, Metivier RJ, Murali VK, Nowak RP, Zhang T, Fischer ES, Gray NS, Jones LH. Gao Y, et al. Among authors: huerta f. J Med Chem. 2023 Apr 27;66(8):5524-5535. doi: 10.1021/acs.jmedchem.2c01864. Epub 2023 Apr 10. J Med Chem. 2023. PMID: 37036171
Development of a covalent cereblon-based PROTAC employing a fluorosulfate warhead.
Nowak RP, Ragosta L, Huerta F, Liu H, Ficarro SB, Cruite JT, Metivier RJ, Donovan KA, Marto JA, Fischer ES, Zerfas BL, Jones LH. Nowak RP, et al. Among authors: huerta f. RSC Chem Biol. 2023 Aug 31;4(11):906-912. doi: 10.1039/d3cb00103b. eCollection 2023 Nov 1. RSC Chem Biol. 2023. PMID: 37920397 Free PMC article.