Filograna R - Search Results

1

Mammalian RNase H1 directs RNA primer formation for mtDNA replication initiation and is also necessary for mtDNA replication completion.

Misic J, Milenkovic D, Al-Behadili A, Xie X, Jiang M, Jiang S, Filograna R, Koolmeister C, Siira SJ, Jenninger L, Filipovska A, Clausen AR, Caporali L, Valentino ML, La Morgia C, Carelli V, Nicholls TJ, Wredenberg A, Falkenberg M, Larsson NG. Misic J, et al. Among authors: filograna r. Nucleic Acids Res. 2022 Aug 26;50(15):8749-8766. doi: 10.1093/nar/gkac661. Nucleic Acids Res. 2022. PMID: 35947649 Free PMC article.

2

A Phenotype-Driven Approach to Generate Mouse Models with Pathogenic mtDNA Mutations Causing Mitochondrial Disease.

Kauppila JHK, Baines HL, Bratic A, Simard ML, Freyer C, Mourier A, Stamp C, Filograna R, Larsson NG, Greaves LC, Stewart JB. Kauppila JHK, et al. Among authors: filograna r. Cell Rep. 2016 Sep 13;16(11):2980-2990. doi: 10.1016/j.celrep.2016.08.037. Cell Rep. 2016. PMID: 27626666 Free PMC article.

3

Modulation of mtDNA copy number ameliorates the pathological consequences of a heteroplasmic mtDNA mutation in the mouse.

Filograna R, Koolmeister C, Upadhyay M, Pajak A, Clemente P, Wibom R, Simard ML, Wredenberg A, Freyer C, Stewart JB, Larsson NG. Filograna R, et al. Sci Adv. 2019 Apr 3;5(4):eaav9824. doi: 10.1126/sciadv.aav9824. eCollection 2019 Apr. Sci Adv. 2019. PMID: 30949583 Free PMC article.

4

Defects of mitochondrial RNA turnover lead to the accumulation of double-stranded RNA in vivo.

Pajak A, Laine I, Clemente P, El-Fissi N, Schober FA, Maffezzini C, Calvo-Garrido J, Wibom R, Filograna R, Dhir A, Wedell A, Freyer C, Wredenberg A. Pajak A, et al. Among authors: filograna r. PLoS Genet. 2019 Jul 31;15(7):e1008240. doi: 10.1371/journal.pgen.1008240. eCollection 2019 Jul. PLoS Genet. 2019. PMID: 31365523 Free PMC article.

5

Mitochondrial DNA copy number in human disease: the more the better?

Filograna R, Mennuni M, Alsina D, Larsson NG. Filograna R, et al. FEBS Lett. 2021 Apr;595(8):976-1002. doi: 10.1002/1873-3468.14021. Epub 2020 Dec 25. FEBS Lett. 2021. PMID: 33314045 Free PMC article. Review.

6

Mitochondrial dysfunction in adult midbrain dopamine neurons triggers an early immune response.

Filograna R, Lee S, Tiklová K, Mennuni M, Jonsson V, Ringnér M, Gillberg L, Sopova E, Shupliakov O, Koolmeister C, Olson L, Perlmann T, Larsson NG. Filograna R, et al. PLoS Genet. 2021 Sep 27;17(9):e1009822. doi: 10.1371/journal.pgen.1009822. eCollection 2021 Sep. PLoS Genet. 2021. PMID: 34570766 Free PMC article.

7

Metabolic resistance to the inhibition of mitochondrial transcription revealed by CRISPR-Cas9 screen.

Mennuni M, Filograna R, Felser A, Bonekamp NA, Giavalisco P, Lytovchenko O, Larsson NG. Mennuni M, et al. Among authors: filograna r. EMBO Rep. 2022 Jan 5;23(1):e53054. doi: 10.15252/embr.202153054. Epub 2021 Nov 15. EMBO Rep. 2022. PMID: 34779571 Free PMC article.

8

A role for BCL2L13 and autophagy in germline purifying selection of mtDNA.

Kremer LS, Bozhilova LV, Rubalcava-Gracia D, Filograna R, Upadhyay M, Koolmeister C, Chinnery PF, Larsson NG. Kremer LS, et al. Among authors: filograna r. PLoS Genet. 2023 Jan 6;19(1):e1010573. doi: 10.1371/journal.pgen.1010573. eCollection 2023 Jan. PLoS Genet. 2023. PMID: 36608143 Free PMC article.

9

Preserved respiratory chain capacity and physiology in mice with profoundly reduced levels of mitochondrial respirasomes.

Milenkovic D, Misic J, Hevler JF, Molinié T, Chung I, Atanassov I, Li X, Filograna R, Mesaros A, Mourier A, Heck AJR, Hirst J, Larsson NG. Milenkovic D, et al. Among authors: filograna r. Cell Metab. 2023 Oct 3;35(10):1799-1813.e7. doi: 10.1016/j.cmet.2023.07.015. Epub 2023 Aug 25. Cell Metab. 2023. PMID: 37633273 Free article.

10

Antigen receptor stimulation induces purifying selection against pathogenic mitochondrial tRNA mutations.

Zhang J, Koolmeister C, Han J, Filograna R, Hanke L, Àdori M, Sheward DJ, Teifel S, Gopalakrishna S, Shao Q, Liu Y, Zhu K, Harris RA, McInerney G, Murrell B, Aoun M, Bäckdahl L, Holmdahl R, Pekalski M, Wedell A, Engvall M, Wredenberg A, Karlsson Hedestam GB, Castro Dopico X, Rorbach J. Zhang J, et al. Among authors: filograna r. JCI Insight. 2023 Sep 8;8(17):e167656. doi: 10.1172/jci.insight.167656. JCI Insight. 2023. PMID: 37681412 Free PMC article.

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