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Specific targeting highly conserved residues in the HIV-1 reverse transcriptase primer grip region. Design, synthesis, and biological evaluation of novel, potent, and broad spectrum NNRTIs with antiviral activity.
Fattorusso C, Gemma S, Butini S, Huleatt P, Catalanotti B, Persico M, De Angelis M, Fiorini I, Nacci V, Ramunno A, Rodriquez M, Greco G, Novellino E, Bergamini A, Marini S, Coletta M, Maga G, Spadari S, Campiani G. Fattorusso C, et al. Among authors: fiorini i. J Med Chem. 2005 Nov 17;48(23):7153-65. doi: 10.1021/jm050257d. J Med Chem. 2005. PMID: 16279773
Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors: design, synthesis, and effects on behavior.
Butini S, Gemma S, Campiani G, Franceschini S, Trotta F, Borriello M, Ceres N, Ros S, Coccone SS, Bernetti M, De Angelis M, Brindisi M, Nacci V, Fiorini I, Novellino E, Cagnotto A, Mennini T, Sandager-Nielsen K, Andreasen JT, Scheel-Kruger J, Mikkelsen JD, Fattorusso C. Butini S, et al. Among authors: fiorini i. J Med Chem. 2009 Jan 8;52(1):151-69. doi: 10.1021/jm800689g. J Med Chem. 2009. PMID: 19072656
Specific targeting of peripheral serotonin 5-HT(3) receptors. Synthesis, biological investigation, and structure-activity relationships.
Morelli E, Gemma S, Budriesi R, Campiani G, Novellino E, Fattorusso C, Catalanotti B, Coccone SS, Ros S, Borrelli G, Persico M, Fiorini I, Nacci V, Ioan P, Chiarini A, Hamon M, Cagnotto A, Mennini T, Fracasso C, Colovic M, Caccia S, Butini S. Morelli E, et al. Among authors: fiorini i. J Med Chem. 2009 Jun 11;52(11):3548-62. doi: 10.1021/jm900018b. J Med Chem. 2009. PMID: 19425598
A concerted study using binding measurements, X-ray structural data, and molecular modeling on the stereochemical features responsible for the affinity of 6-arylpyrrolo[2,1-d][1,5]benzothiazepines toward mitochondrial benzodiazepine receptors.
Dalpiaz A, Bertolasi V, Borea PA, Nacci V, Fiorini I, Campiani G, Mennini T, Manzoni C, Novellino E, Greco G. Dalpiaz A, et al. Among authors: fiorini i. J Med Chem. 1995 Nov 10;38(23):4730-8. doi: 10.1021/jm00023a013. J Med Chem. 1995. PMID: 7473601
A comparative molecular field analysis model for 6-arylpyrrolo[2,1-d] [1,5]benzothiazepines binding selectively to the mitochondrial benzodiazepine receptor.
Greco G, Novellino E, Fiorini I, Nacci V, Campiani G, Ciani SM, Garofalo A, Bernasconi P, Mennini T. Greco G, et al. Among authors: fiorini i. J Med Chem. 1994 Nov 25;37(24):4100-8. doi: 10.1021/jm00050a007. J Med Chem. 1994. PMID: 7990110
A series of 42 6-arylpyrrolo[2,1-d][1,5]benzothiazepines, which we have recently described as selective ligands of the mitochondrial benzodiazepine receptor (MBR) (Fiorini I.; et al. J. Med. Chem. 1994, 37, 1427-1438), have been investigated using the comparative mo …
A series of 42 6-arylpyrrolo[2,1-d][1,5]benzothiazepines, which we have recently described as selective ligands of the mitochondrial benzodi …
55 results