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Recent insights into cell death and autophagy.
Fitzwalter BE, Thorburn A. Fitzwalter BE, et al. FEBS J. 2015 Nov;282(22):4279-88. doi: 10.1111/febs.13515. Epub 2015 Oct 1. FEBS J. 2015. PMID: 26367268 Free PMC article. Review.
FOXO3 links autophagy to apoptosis.
Fitzwalter BE, Thorburn A. Fitzwalter BE, et al. Autophagy. 2018;14(8):1467-1468. doi: 10.1080/15548627.2018.1475819. Epub 2018 Jul 21. Autophagy. 2018. PMID: 29938591 Free PMC article.
Cancer Cells Upregulate NRF2 Signaling to Adapt to Autophagy Inhibition.
Towers CG, Fitzwalter BE, Regan D, Goodspeed A, Morgan MJ, Liu CW, Gustafson DL, Thorburn A. Towers CG, et al. Among authors: fitzwalter be. Dev Cell. 2019 Sep 23;50(6):690-703.e6. doi: 10.1016/j.devcel.2019.07.010. Epub 2019 Aug 1. Dev Cell. 2019. PMID: 31378590 Free PMC article.
Autophagy inhibition overcomes multiple mechanisms of resistance to BRAF inhibition in brain tumors.
Mulcahy Levy JM, Zahedi S, Griesinger AM, Morin A, Davies KD, Aisner DL, Kleinschmidt-DeMasters BK, Fitzwalter BE, Goodall ML, Thorburn J, Amani V, Donson AM, Birks DK, Mirsky DM, Hankinson TC, Handler MH, Green AL, Vibhakar R, Foreman NK, Thorburn A. Mulcahy Levy JM, et al. Among authors: fitzwalter be. Elife. 2017 Jan 17;6:e19671. doi: 10.7554/eLife.19671. Elife. 2017. PMID: 28094001 Free PMC article.
Metastatic cells are preferentially vulnerable to lysosomal inhibition.
Morgan MJ, Fitzwalter BE, Owens CR, Powers RK, Sottnik JL, Gamez G, Costello JC, Theodorescu D, Thorburn A. Morgan MJ, et al. Among authors: fitzwalter be. Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):E8479-E8488. doi: 10.1073/pnas.1706526115. Epub 2018 Aug 20. Proc Natl Acad Sci U S A. 2018. PMID: 30127018 Free PMC article.
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