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Impaired ribosome biogenesis checkpoint activation induces p53-dependent MCL-1 degradation and MYC-driven lymphoma death.
Domostegui A, Peddigari S, Mercer CA, Iannizzotto F, Rodriguez ML, Garcia-Cajide M, Amador V, Diepstraten ST, Kelly GL, Salazar R, Kozma SC, Kusnadi EP, Kang J, Gentilella A, Pearson RB, Thomas G, Pelletier J. Domostegui A, et al. Among authors: iannizzotto f. Blood. 2021 Jun 17;137(24):3351-3364. doi: 10.1182/blood.2020007452. Blood. 2021. PMID: 33512431 Free PMC article.
The 40S-LARP1 complex reprograms the cellular translatome upon mTOR inhibition to preserve the protein synthetic capacity.
Fuentes P, Pelletier J, Martinez-Herráez C, Diez-Obrero V, Iannizzotto F, Rubio T, Garcia-Cajide M, Menoyo S, Moreno V, Salazar R, Tauler A, Gentilella A. Fuentes P, et al. Among authors: iannizzotto f. Sci Adv. 2021 Nov 26;7(48):eabg9275. doi: 10.1126/sciadv.abg9275. Epub 2021 Nov 26. Sci Adv. 2021. PMID: 34818049 Free PMC article.