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Randomised clinical trial: anti-viral activity of ANA773, an oral inducer of endogenous interferons acting via TLR7, in chronic HCV.
Bergmann JF, de Bruijne J, Hotho DM, de Knegt RJ, Boonstra A, Weegink CJ, van Vliet AA, van de Wetering J, Fletcher SP, Bauman LA, Rahimy M, Appleman JR, Freddo JL, Janssen HL, Reesink HW. Bergmann JF, et al. Among authors: fletcher sp. Aliment Pharmacol Ther. 2011 Aug;34(4):443-53. doi: 10.1111/j.1365-2036.2011.04745.x. Epub 2011 Jun 26. Aliment Pharmacol Ther. 2011. PMID: 21707679 Free article. Clinical Trial.
The pharmacology of endosomal TLR agonists in viral disease.
Averett DR, Fletcher SP, Li W, Webber SE, Appleman JR. Averett DR, et al. Among authors: fletcher sp. Biochem Soc Trans. 2007 Dec;35(Pt 6):1468-72. doi: 10.1042/BST0351468. Biochem Soc Trans. 2007. PMID: 18031247 Review.
Safety, pharmacodynamics, and antiviral activity of selgantolimod in viremic patients with chronic hepatitis B virus infection.
Janssen HL, Lim YS, Kim HJ, Sowah L, Tseng CH, Coffin CS, Elkhashab M, Ahn SH, Nguyen AH, Chen D, Wallin JJ, Fletcher SP, McDonald C, Yang JC, Gaggar A, Brainard DM, Fung S, Kim YJ, Kao JH, Chuang WL, Brooks AE, Dunbar PR. Janssen HL, et al. Among authors: fletcher sp. JHEP Rep. 2023 Nov 30;6(2):100975. doi: 10.1016/j.jhepr.2023.100975. eCollection 2024 Feb. JHEP Rep. 2023. PMID: 38274492 Free PMC article.
Alternating Arenavirus Vector Immunization Generates Robust Polyfunctional Genotype Cross-Reactive Hepatitis B Virus-Specific CD8 T-Cell Responses and High Anti-Hepatitis B Surface Antigen Titers.
Schmidt S, Mengistu M, Daffis S, Ahmadi-Erber S, Deutschmann D, Grigoriev T, Chu R, Leung C, Tomkinson A, Uddin MN, Moshkani S, Robek MD, Perry J, Lauterbach H, Orlinger K, Fletcher SP, Balsitis S. Schmidt S, et al. Among authors: fletcher sp. J Infect Dis. 2024 Apr 12;229(4):1077-1087. doi: 10.1093/infdis/jiad340. J Infect Dis. 2024. PMID: 37602681
142 results