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Rapamycin extends murine lifespan but has limited effects on aging.
Neff F, Flores-Dominguez D, Ryan DP, Horsch M, Schröder S, Adler T, Afonso LC, Aguilar-Pimentel JA, Becker L, Garrett L, Hans W, Hettich MM, Holtmeier R, Hölter SM, Moreth K, Prehn C, Puk O, Rácz I, Rathkolb B, Rozman J, Naton B, Ordemann R, Adamski J, Beckers J, Bekeredjian R, Busch DH, Ehninger G, Graw J, Höfler H, Klingenspor M, Klopstock T, Ollert M, Stypmann J, Wolf E, Wurst W, Zimmer A, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Ehninger D. Neff F, et al. Among authors: flores dominguez d. J Clin Invest. 2013 Aug;123(8):3272-91. doi: 10.1172/JCI67674. Epub 2013 Jul 25. J Clin Invest. 2013. PMID: 23863708 Free PMC article.
Inhibition of the MID1 protein complex: a novel approach targeting APP protein synthesis.
Matthes F, Hettich MM, Schilling J, Flores-Dominguez D, Blank N, Wiglenda T, Buntru A, Wolf H, Weber S, Vorberg I, Dagane A, Dittmar G, Wanker E, Ehninger D, Krauss S. Matthes F, et al. Among authors: flores dominguez d. Cell Death Discov. 2018 Jan 29;4:4. doi: 10.1038/s41420-017-0003-8. eCollection 2018 Dec. Cell Death Discov. 2018. PMID: 29531801 Free PMC article.