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Structure-activity relationships and pharmacokinetic parameters of quinoline acylsulfonamides as potent and selective antagonists of the EP(4) receptor.
Burch JD, Belley M, Fortin R, Deschênes D, Girard M, Colucci J, Farand J, Therien AG, Mathieu MC, Denis D, Vigneault E, Lévesque JF, Gagné S, Wrona M, Xu D, Clark P, Rowland S, Han Y. Burch JD, et al. Among authors: fortin r. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2048-54. doi: 10.1016/j.bmcl.2008.01.103. Epub 2008 Jan 31. Bioorg Med Chem Lett. 2008. PMID: 18291643
Solid-phase analogue synthesis of caspase-3 inhibitors via palladium-catalyzed amination of 3-bromopyrazinones.
Isabel E, Aspiotis R, Black WC, Colucci J, Fortin R, Giroux A, Grimm EL, Han Y, Mellon C, Nicholson DW, Rasper DM, Renaud J, Roy S, Tam J, Tawa P, Vaillancourt JP, Xanthoudakis S, Zamboni RJ. Isabel E, et al. Among authors: fortin r. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1671-4. doi: 10.1016/j.bmcl.2006.12.110. Epub 2007 Jan 11. Bioorg Med Chem Lett. 2007. PMID: 17251019
2-Pyridinyl-3-(4-methylsulfonyl)phenylpyridines: selective and orally active cyclooxygenase-2 inhibitors.
Friesen RW, Brideau C, Chan CC, Charleson S, Deschênes D, Dubé D, Ethier D, Fortin R, Gauthier JY, Girard Y, Gordon R, Greig GM, Riendeau D, Savoie C, Wang Z, Wong E, Visco D, Xu LJ, Young RN. Friesen RW, et al. Among authors: fortin r. Bioorg Med Chem Lett. 1998 Oct 6;8(19):2777-82. doi: 10.1016/s0960-894x(98)00499-5. Bioorg Med Chem Lett. 1998. PMID: 9873621
Identification of a new biaryl scaffold generating potent renin inhibitors.
Lacombe P, Aspiotis R, Bayly C, Chen A, Dubé D, Fortin R, Gallant M, Juteau H, Liu S, McKay D, Roy P, Wu T. Lacombe P, et al. Among authors: fortin r. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5822-6. doi: 10.1016/j.bmcl.2010.07.127. Epub 2010 Aug 3. Bioorg Med Chem Lett. 2010. PMID: 20728350
L-648,051: an aerosol active leukotriene D4 receptor antagonist.
Jones TR, Guindon Y, Champion E, Charette L, DeHaven RN, Denis D, Ethier D, Ford-Hutchinson AW, Fortin R, Frenette R, et al. Jones TR, et al. Among authors: fortin r. Adv Prostaglandin Thromboxane Leukot Res. 1987;17B:1012-7. Adv Prostaglandin Thromboxane Leukot Res. 1987. PMID: 2823551 No abstract available.
Design and synthesis of sodium (beta R*, gamma S*)-4-[[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propyl] thio]-gamma-hydroxy-beta-methylbenzenebutanoate: a novel, selective, and orally active receptor antagonist of leukotriene D4.
Young RN, Bélanger P, Champion E, DeHaven RN, Denis D, Ford-Hutchinson AW, Fortin R, Frenette R, Gauthier JY, Gillard J, et al. Young RN, et al. Among authors: fortin r. J Med Chem. 1986 Sep;29(9):1573-6. doi: 10.1021/jm00159a003. J Med Chem. 1986. PMID: 3746809 No abstract available.
72 results