Fortin R - Search Results

1

L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2 - dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor.

Gillard J, Ford-Hutchinson AW, Chan C, Charleson S, Denis D, Foster A, Fortin R, Leger S, McFarlane CS, Morton H, et al. Gillard J, et al. Among authors: fortin r. Can J Physiol Pharmacol. 1989 May;67(5):456-64. doi: 10.1139/y89-073. Can J Physiol Pharmacol. 1989. PMID: 2548691

2

Pharmacology of MK-0591 (3-[1-(4-chlorobenzyl)-3-(t-butylthio)-5-(quinolin-2-yl-methoxy)- indol-2-yl]-2,2-dimethyl propanoic acid), a potent, orally active leukotriene biosynthesis inhibitor.

Brideau C, Chan C, Charleson S, Denis D, Evans JF, Ford-Hutchinson AW, Fortin R, Gillard JW, Guay J, Guévremont D, et al. Brideau C, et al. Among authors: fortin r. Can J Physiol Pharmacol. 1992 Jun;70(6):799-807. doi: 10.1139/y92-107. Can J Physiol Pharmacol. 1992. PMID: 1330258

3

Identification and isolation of a membrane protein necessary for leukotriene production.

Miller DK, Gillard JW, Vickers PJ, Sadowski S, Léveillé C, Mancini JA, Charleson P, Dixon RA, Ford-Hutchinson AW, Fortin R, et al. Miller DK, et al. Among authors: fortin r. Nature. 1990 Jan 18;343(6255):278-81. doi: 10.1038/343278a0. Nature. 1990. PMID: 2300172

4

L-648,051: an aerosol active leukotriene D4 receptor antagonist.

Jones TR, Guindon Y, Champion E, Charette L, DeHaven RN, Denis D, Ethier D, Ford-Hutchinson AW, Fortin R, Frenette R, et al. Jones TR, et al. Among authors: fortin r. Adv Prostaglandin Thromboxane Leukot Res. 1987;17B:1012-7. Adv Prostaglandin Thromboxane Leukot Res. 1987. PMID: 2823551 No abstract available.

5

Novel arylthio- and arylsulfonylpropyloxyacetophenones: design and synthesis of L-648,051 and L-649,923, potent antagonists of leukotriene D4.

Young RN, Jones TR, Atkinson JG, Bélanger P, Champion E, Denis D, DeHaven RN, Ford-Hutchinson AW, Fortin R, Frenette R, et al. Young RN, et al. Among authors: fortin r. Adv Prostaglandin Thromboxane Leukot Res. 1987;17A:544-8. Adv Prostaglandin Thromboxane Leukot Res. 1987. PMID: 2959111 No abstract available.

6

L-648,051, sodium 4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)- propylsulfonyl]-gamma-oxo-benzenebutanoate: a leukotriene D4 receptor antagonist.

Jones TR, Guindon Y, Young R, Champion E, Charette L, Denis D, Ethier D, Hamel R, Ford-Hutchinson AW, Fortin R, et al. Jones TR, et al. Among authors: fortin r. Can J Physiol Pharmacol. 1986 Dec;64(12):1535-42. doi: 10.1139/y86-258. Can J Physiol Pharmacol. 1986. PMID: 3030524

7

Pharmacology of L-655,240 (3-[1-(4-chlorobenzyl)-5-fluoro-3-methyl-indol-2-yl]2,2-dimethylpro pan oic acid); a potent, selective thromboxane/prostaglandin endoperoxide antagonist.

Hall RA, Gillard J, Guindon Y, Letts G, Champion E, Ethier D, Evans J, Ford-Hutchinson AW, Fortin R, Jones TR, et al. Hall RA, et al. Among authors: fortin r. Eur J Pharmacol. 1987 Mar 17;135(2):193-201. doi: 10.1016/0014-2999(87)90611-x. Eur J Pharmacol. 1987. PMID: 3582493

8

Substituted thiopyrano[2,3,4-c,d]indoles as potent, selective, and orally active inhibitors of 5-lipoxygenase. Synthesis and biological evaluation of L-691,816.

Hutchinson JH, Riendeau D, Brideau C, Chan C, Delorme D, Denis D, Falgueyret JP, Fortin R, Guay J, Hamel P, et al. Hutchinson JH, et al. Among authors: fortin r. J Med Chem. 1993 Sep 17;36(19):2771-87. doi: 10.1021/jm00071a008. J Med Chem. 1993. PMID: 8410991

9

Dioxabicyclooctanyl naphthalenenitriles as nonredox 5-lipoxygenase inhibitors: structure-activity relationship study directed toward the improvement of metabolic stability.

Delorme D, Ducharme Y, Brideau C, Chan CC, Chauret N, Desmarais S, Dubé D, Falgueyret JP, Fortin R, Guay J, Hamel P, Jones TR, Lépine C, Li C, McAuliffe M, McFarlane CS, Nicoll-Griffith DA, Riendeau D, Yergey JA, Girard Y. Delorme D, et al. Among authors: fortin r. J Med Chem. 1996 Sep 27;39(20):3951-70. doi: 10.1021/jm960301c. J Med Chem. 1996. PMID: 8831761

10

The use of synthetic thromboxane A2 (TXA2-S) and a new class of thromboxane antagonists, indole-2-propanoic acids to characterize the thromboxane receptor.

Gillard JW, Morton HE, Fortin R, Yoakim C, Girard Y, Lord A, Ethier D, Leveille C, Letts G, Evans J, et al. Gillard JW, et al. Among authors: fortin r. Prog Clin Biol Res. 1989;301:579-83. Prog Clin Biol Res. 1989. PMID: 2529557 No abstract available.

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