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Liver-enriched transcription factor expression relates to chronic hepatic failure in humans.
Guzman-Lepe J, Cervantes-Alvarez E, Collin de l'Hortet A, Wang Y, Mars WM, Oda Y, Bekki Y, Shimokawa M, Wang H, Yoshizumi T, Maehara Y, Bell A, Fox IJ, Takeishi K, Soto-Gutierrez A. Guzman-Lepe J, et al. Among authors: fox ij. Hepatol Commun. 2018 Mar 23;2(5):582-594. doi: 10.1002/hep4.1172. eCollection 2018 May. Hepatol Commun. 2018. PMID: 29761173 Free PMC article.
Cellular Location of HNF4α is Linked With Terminal Liver Failure in Humans.
Florentino RM, Fraunhoffer NA, Morita K, Takeishi K, Ostrowska A, Achreja A, Animasahun O, Haep N, Arazov S, Agarwal N, Collin de l'Hortet A, Guzman-Lepe J, Tafaleng EN, Mukherjee A, Troy K, Banerjee S, Paranjpe S, Michalopoulos GK, Bell A, Nagrath D, Hainer SJ, Fox IJ, Soto-Gutierrez A. Florentino RM, et al. Among authors: fox ij. Hepatol Commun. 2020 Apr 21;4(6):859-875. doi: 10.1002/hep4.1505. eCollection 2020 Jun. Hepatol Commun. 2020. PMID: 32490322 Free PMC article.
Hepatocyte Nuclear Factor 4 alpha 2 Messenger RNA Reprograms Liver-Enriched Transcription Factors and Functional Proteins in End-Stage Cirrhotic Human Hepatocytes.
Tafaleng EN, Mukherjee A, Bell A, Morita K, Guzman-Lepe J, Haep N, Florentino RM, Diaz-Aragon R, Frau C, Ostrowska A, Schultz JR, Martini PGV, Soto-Gutierrez A, Fox IJ. Tafaleng EN, et al. Among authors: fox ij. Hepatol Commun. 2021 Nov;5(11):1911-1926. doi: 10.1002/hep4.1763. Epub 2021 Jul 1. Hepatol Commun. 2021. PMID: 34558820 Free PMC article.
A switch in the source of ATP production and a loss in capacity to perform glycolysis are hallmarks of hepatocyte failure in advance liver disease.
Nishikawa T, Bellance N, Damm A, Bing H, Zhu Z, Handa K, Yovchev MI, Sehgal V, Moss TJ, Oertel M, Ram PT, Pipinos II, Soto-Gutierrez A, Fox IJ, Nagrath D. Nishikawa T, et al. Among authors: fox ij. J Hepatol. 2014 Jun;60(6):1203-11. doi: 10.1016/j.jhep.2014.02.014. Epub 2014 Feb 26. J Hepatol. 2014. PMID: 24583248 Free PMC article.
Generation of Human Fatty Livers Using Custom-Engineered Induced Pluripotent Stem Cells with Modifiable SIRT1 Metabolism.
Collin de l'Hortet A, Takeishi K, Guzman-Lepe J, Morita K, Achreja A, Popovic B, Wang Y, Handa K, Mittal A, Meurs N, Zhu Z, Weinberg F, Salomon M, Fox IJ, Deng CX, Nagrath D, Soto-Gutierrez A. Collin de l'Hortet A, et al. Among authors: fox ij. Cell Metab. 2019 Aug 6;30(2):385-401.e9. doi: 10.1016/j.cmet.2019.06.017. Cell Metab. 2019. PMID: 31390551 Free PMC article.
Assembly and Function of a Bioengineered Human Liver for Transplantation Generated Solely from Induced Pluripotent Stem Cells.
Takeishi K, Collin de l'Hortet A, Wang Y, Handa K, Guzman-Lepe J, Matsubara K, Morita K, Jang S, Haep N, Florentino RM, Yuan F, Fukumitsu K, Tobita K, Sun W, Franks J, Delgado ER, Shapiro EM, Fraunhoffer NA, Duncan AW, Yagi H, Mashimo T, Fox IJ, Soto-Gutierrez A. Takeishi K, et al. Among authors: fox ij. Cell Rep. 2020 Jun 2;31(9):107711. doi: 10.1016/j.celrep.2020.107711. Cell Rep. 2020. PMID: 32492423 Free PMC article.
Resetting the transcription factor network reverses terminal chronic hepatic failure.
Nishikawa T, Bell A, Brooks JM, Setoyama K, Melis M, Han B, Fukumitsu K, Handa K, Tian J, Kaestner KH, Vodovotz Y, Locker J, Soto-Gutierrez A, Fox IJ. Nishikawa T, et al. Among authors: fox ij. J Clin Invest. 2015 Apr;125(4):1533-44. doi: 10.1172/JCI73137. Epub 2015 Mar 16. J Clin Invest. 2015. PMID: 25774505 Free PMC article.
Synthetic human livers for modeling metabolic diseases.
Tafaleng EN, Malizio MR, Fox IJ, Soto-Gutierrez A. Tafaleng EN, et al. Among authors: fox ij. Curr Opin Gastroenterol. 2021 May 1;37(3):224-230. doi: 10.1097/MOG.0000000000000726. Curr Opin Gastroenterol. 2021. PMID: 33769378 Free PMC article. Review.
184 results