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Trehalose-based neuroprotective autophagy inducers.
Assoni G, Frapporti G, Colombo E, Gornati D, Perez-Carrion MD, Polito L, Seneci P, Piccoli G, Arosio D. Assoni G, et al. Among authors: frapporti g. Bioorg Med Chem Lett. 2021 May 15;40:127929. doi: 10.1016/j.bmcl.2021.127929. Epub 2021 Mar 9. Bioorg Med Chem Lett. 2021. PMID: 33705903
[No title available]
[No authors listed] [No authors listed] PMID: 33563982
Kinase inhibition of G2019S-LRRK2 enhances autolysosome formation and function to reduce endogenous alpha-synuclein intracellular inclusions.
Obergasteiger J, Frapporti G, Lamonaca G, Pizzi S, Picard A, Lavdas AA, Pischedda F, Piccoli G, Hilfiker S, Lobbestael E, Baekelandt V, Hicks AA, Corti C, Pramstaller PP, Volta M. Obergasteiger J, et al. Among authors: frapporti g. Cell Death Discov. 2020 Jun 8;6:45. doi: 10.1038/s41420-020-0279-y. eCollection 2020. Cell Death Discov. 2020. PMID: 32550012 Free PMC article.
The small GTPase Rit2 modulates LRRK2 kinase activity, is required for lysosomal function and protects against alpha-synuclein neuropathology.
Obergasteiger J, Castonguay AM, Pizzi S, Magnabosco S, Frapporti G, Lobbestael E, Baekelandt V, Hicks AA, Pramstaller PP, Gravel C, Corti C, Lévesque M, Volta M. Obergasteiger J, et al. Among authors: frapporti g. NPJ Parkinsons Dis. 2023 Mar 27;9(1):44. doi: 10.1038/s41531-023-00484-2. NPJ Parkinsons Dis. 2023. PMID: 36973269 Free PMC article.
16 results