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Page 1
A quantitative approach for measuring the reservoir of latent HIV-1 proviruses.
Bruner KM, Wang Z, Simonetti FR, Bender AM, Kwon KJ, Sengupta S, Fray EJ, Beg SA, Antar AAR, Jenike KM, Bertagnolli LN, Capoferri AA, Kufera JT, Timmons A, Nobles C, Gregg J, Wada N, Ho YC, Zhang H, Margolick JB, Blankson JN, Deeks SG, Bushman FD, Siliciano JD, Laird GM, Siliciano RF. Bruner KM, et al. Among authors: fray ej. Nature. 2019 Feb;566(7742):120-125. doi: 10.1038/s41586-019-0898-8. Epub 2019 Jan 30. Nature. 2019. PMID: 30700913 Free PMC article.
CD8+ lymphocytes do not impact SIV reservoir establishment under ART.
Statzu M, Jin W, Fray EJ, Wong AKH, Kumar MR, Ferrer E, Docken SS, Pinkevych M, McBrien JB, Fennessey CM, Keele BF, Liang S, Harper JL, Mutascio S, Franchitti L, Wang H, Cicetti D, Bosinger SE, Carnathan DG, Vanderford TH, Margolis DM, Garcia-Martinez JV, Chahroudi A, Paiardini M, Siliciano J, Davenport MP, Kulpa DA, Siliciano RS, Silvestri G. Statzu M, et al. Among authors: fray ej. Nat Microbiol. 2023 Feb;8(2):299-308. doi: 10.1038/s41564-022-01311-9. Epub 2023 Jan 23. Nat Microbiol. 2023. PMID: 36690860 Free PMC article.
Allogeneic immunity clears latent virus following allogeneic stem cell transplantation in SIV-infected ART-suppressed macaques.
Wu HL, Busman-Sahay K, Weber WC, Waytashek CM, Boyle CD, Bateman KB, Reed JS, Hwang JM, Shriver-Munsch C, Swanson T, Northrup M, Armantrout K, Price H, Robertson-LeVay M, Uttke S, Kumar MR, Fray EJ, Taylor-Brill S, Bondoc S, Agnor R, Junell SL, Legasse AW, Moats C, Bochart RM, Sciurba J, Bimber BN, Sullivan MN, Dozier B, MacAllister RP, Hobbs TR, Martin LD, Panoskaltsis-Mortari A, Colgin LMA, Siliciano RF, Siliciano JD, Estes JD, Smedley JV, Axthelm MK, Meyers G, Maziarz RT, Burwitz BJ, Stanton JJ, Sacha JB. Wu HL, et al. Among authors: fray ej. Immunity. 2023 Jul 11;56(7):1649-1663.e5. doi: 10.1016/j.immuni.2023.04.019. Epub 2023 May 25. Immunity. 2023. PMID: 37236188
The latent reservoir of inducible, infectious HIV-1 does not decrease despite decades of antiretroviral therapy.
McMyn NF, Varriale J, Fray EJ, Zitzmann C, MacLeod H, Lai J, Singhal A, Moskovljevic M, Garcia MA, Lopez BM, Hariharan V, Rhodehouse K, Lynn K, Tebas P, Mounzer K, Montaner LJ, Benko E, Kovacs C, Hoh R, Simonetti FR, Laird GM, Deeks SG, Ribeiro RM, Perelson AS, Siliciano RF, Siliciano JM. McMyn NF, et al. Among authors: fray ej. J Clin Invest. 2023 Sep 1;133(17):e171554. doi: 10.1172/JCI171554. J Clin Invest. 2023. PMID: 37463049 Free PMC article.
TCR-mimic bispecific antibodies to target the HIV-1 reservoir.
Sengupta S, Board NL, Wu F, Moskovljevic M, Douglass J, Zhang J, Reinhold BR, Duke-Cohan J, Yu J, Reed MC, Tabdili Y, Azurmendi A, Fray EJ, Zhang H, Hsiue EH, Jenike K, Ho YC, Gabelli SB, Kinzler KW, Vogelstein B, Zhou S, Siliciano JD, Sadegh-Nasseri S, Reinherz EL, Siliciano RF. Sengupta S, et al. Among authors: fray ej. Proc Natl Acad Sci U S A. 2022 Apr 12;119(15):e2123406119. doi: 10.1073/pnas.2123406119. Epub 2022 Apr 8. Proc Natl Acad Sci U S A. 2022. PMID: 35394875 Free PMC article.
Therapeutic efficacy of combined active and passive immunization in ART-suppressed, SHIV-infected rhesus macaques.
Walker-Sperling VEK, Mercado NB, Chandrashekar A, Borducchi EN, Liu J, Nkolola JP, Lewis M, Murry JP, Yang Y, Geleziunas R, Robb ML, Michael NL, Pau MG, Wegmann F, Schuitemaker H, Fray EJ, Kumar MR, Siliciano JD, Siliciano RF, Barouch DH. Walker-Sperling VEK, et al. Among authors: fray ej. Nat Commun. 2022 Jun 16;13(1):3463. doi: 10.1038/s41467-022-31196-5. Nat Commun. 2022. PMID: 35710819 Free PMC article.
Antiretroviral therapy reveals triphasic decay of intact SIV genomes and persistence of ancestral variants.
Fray EJ, Wu F, Simonetti FR, Zitzmann C, Sambaturu N, Molina-Paris C, Bender AM, Liu PT, Ventura JD, Wiseman RW, O'Connor DH, Geleziunas R, Leitner T, Ribeiro RM, Perelson AS, Barouch DH, Siliciano JD, Siliciano RF. Fray EJ, et al. Cell Host Microbe. 2023 Mar 8;31(3):356-372.e5. doi: 10.1016/j.chom.2023.01.016. Epub 2023 Feb 20. Cell Host Microbe. 2023. PMID: 36809762 Free PMC article.
Induction of durable remission by dual immunotherapy in SHIV-infected ART-suppressed macaques.
Lim SY, Lee J, Osuna CE, Vikhe P, Schalk DR, Chen E, Fray E, Kumar M, Schultz-Darken N, Rakasz E, Capuano S, Ladd RA, Gil HM, Evans DT, Jeng EK, Seaman M, Martin M, Van Dorp C, Perelson AS, Wong HC, Siliciano JD, Siliciano R, Safrit JT, Nixon DF, Soon-Shiong P, Nussenzweig M, Whitney JB. Lim SY, et al. Among authors: fray e. Science. 2024 Mar 8;383(6687):1104-1111. doi: 10.1126/science.adf7966. Epub 2024 Feb 29. Science. 2024. PMID: 38422185 Free PMC article.
Biphasic decay of intact SHIV genomes following initiation of antiretroviral therapy complicates analysis of interventions targeting the reservoir.
Kumar MR, Fray EJ, Bender AM, Zitzmann C, Ribeiro RM, Perelson AS, Barouch DH, Siliciano JD, Siliciano RF. Kumar MR, et al. Among authors: fray ej. Proc Natl Acad Sci U S A. 2023 Oct 24;120(43):e2313209120. doi: 10.1073/pnas.2313209120. Epub 2023 Oct 16. Proc Natl Acad Sci U S A. 2023. PMID: 37844236 Free PMC article.
Assessing the impact of autologous neutralizing antibodies on viral rebound in postnatally SHIV-infected ART-treated infant rhesus macaques.
Mainou E, Berendam SJ, Obregon-Perko V, Uffman EA, Phan CT, Shaw GM, Bar KJ, Kumar MR, Fray EJ, Siliciano JM, Siliciano RF, Silvestri G, Permar SR, Fouda GG, McCarthy J, Chahroudi A, Conway JM, Chan C. Mainou E, et al. Among authors: fray ej. bioRxiv [Preprint]. 2023 Sep 14:2023.07.22.550159. doi: 10.1101/2023.07.22.550159. bioRxiv. 2023. PMID: 37502921 Free PMC article. Preprint.
19 results