Frei E - Search Results

1

Knockout and humanized mice as suitable tools to identify enzymes metabolizing the human carcinogen aristolochic acid.

Stiborová M, Frei E, Arlt VM, Schmeiser HH. Stiborová M, et al. Among authors: frei e. Xenobiotica. 2014 Jan;44(2):135-45. doi: 10.3109/00498254.2013.848310. Epub 2013 Oct 23. Xenobiotica. 2014. PMID: 24152141 Review.

2

Carcinogenic aristolochic acids upon activation by DT-diaphorase form adducts found in DNA of patients with Chinese herbs nephropathy.

Stiborová M, Frei E, Sopko B, Wiessler M, Schmeiser HH. Stiborová M, et al. Among authors: frei e. Carcinogenesis. 2002 Apr;23(4):617-25. doi: 10.1093/carcin/23.4.617. Carcinogenesis. 2002. PMID: 11960915

3

Human cytosolic enzymes involved in the metabolic activation of carcinogenic aristolochic acid: evidence for reductive activation by human NAD(P)H:quinone oxidoreductase.

Stiborová M, Frei E, Sopko B, Sopková K, Marková V, Lanková M, Kumstýrová T, Wiessler M, Schmeiser HH. Stiborová M, et al. Among authors: frei e. Carcinogenesis. 2003 Oct;24(10):1695-703. doi: 10.1093/carcin/bgg119. Epub 2003 Jul 17. Carcinogenesis. 2003. PMID: 12869422

4

Enzymes involved in the metabolism of the carcinogen 2-nitroanisole: evidence for its oxidative detoxication by human cytochromes P450.

Miksanová M, Sulc M, Rýdlová H, Schmeiser HH, Frei E, Stiborová M. Miksanová M, et al. Among authors: frei e. Chem Res Toxicol. 2004 May;17(5):663-71. doi: 10.1021/tx0499721. Chem Res Toxicol. 2004. PMID: 15144223

5

Human hepatic and renal microsomes, cytochromes P450 1A1/2, NADPH:cytochrome P450 reductase and prostaglandin H synthase mediate the formation of aristolochic acid-DNA adducts found in patients with urothelial cancer.

Stiborová M, Frei E, Hodek P, Wiessler M, Schmeiser HH. Stiborová M, et al. Among authors: frei e. Int J Cancer. 2005 Jan 10;113(2):189-97. doi: 10.1002/ijc.20564. Int J Cancer. 2005. PMID: 15386410 Free article.

6

Identification of a genotoxic mechanism for the carcinogenicity of the environmental pollutant and suspected human carcinogen o-anisidine.

Stiborová M, Miksanová M, Sulc M, Rýdlová H, Schmeiser HH, Frei E. Stiborová M, et al. Among authors: frei e. Int J Cancer. 2005 Sep 20;116(5):667-78. doi: 10.1002/ijc.21122. Int J Cancer. 2005. PMID: 15828049 Free article.

7

The binding of aristolochic acid I to the active site of human cytochromes P450 1A1 and 1A2 explains their potential to reductively activate this human carcinogen.

Stiborová M, Sopko B, Hodek P, Frei E, Schmeiser HH, Hudecek J. Stiborová M, et al. Among authors: frei e. Cancer Lett. 2005 Nov 18;229(2):193-204. doi: 10.1016/j.canlet.2005.06.038. Epub 2005 Aug 24. Cancer Lett. 2005. PMID: 16125300

8

Molecular mechanism of genotoxicity of the environmental pollutant 3-nitrobenzanthrone.

Stiborová M, Arlt VM, Henderson CJ, Wolf CR, Frei E, Schmeiser HH, Phillips DH. Stiborová M, et al. Among authors: frei e. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2005 Dec;149(2):191-7. doi: 10.5507/bp.2005.025. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2005. PMID: 16601755 Review.

9

The environmental pollutant and carcinogen 3-nitrobenzanthrone and its human metabolite 3-aminobenzanthrone are potent inducers of rat hepatic cytochromes P450 1A1 and -1A2 and NAD(P)H:quinone oxidoreductase.

Stiborová M, Dracínská H, Hájková J, Kaderábková P, Frei E, Schmeiser HH, Soucek P, Phillips DH, Arlt VM. Stiborová M, et al. Among authors: frei e. Drug Metab Dispos. 2006 Aug;34(8):1398-405. doi: 10.1124/dmd.106.009373. Epub 2006 May 19. Drug Metab Dispos. 2006. PMID: 16714372

10

Oxidative detoxication of carcinogenic 2-nitroanisole by human, rat and rabbit cytochrome P450.

Dracínska H, Miksanová M, Svobodová M, Smrcek S, Frei E, Schmeiser HH, Stiborová M. Dracínska H, et al. Among authors: frei e. Neuro Endocrinol Lett. 2006 Dec;27 Suppl 2:9-13. Neuro Endocrinol Lett. 2006. PMID: 17159769

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