Fromholt S - Search Results

1

Soluble brain homogenates from diverse human and mouse sources preferentially seed diffuse Aβ plaque pathology when injected into newborn mouse hosts.

Moore BD, Levites Y, Xu G, Hampton H, Adamo MF, Croft CL, Futch HS, Moran C, Fromholt S, Janus C, Prokop S, Dickson D, Lewis J, Giasson BI, Golde TE, Borchelt DR. Moore BD, et al. Among authors: fromholt s. Free Neuropathol. 2022 Jan 11;3(9):3-9. doi: 10.17879/freeneuropathology-2022-3766. Epub 2022 Mar 23. Free Neuropathol. 2022. PMID: 35494163 Free PMC article.

2

Transgenic mice expressing caspase-6-derived N-terminal fragments of mutant huntingtin develop neurologic abnormalities with predominant cytoplasmic inclusion pathology composed largely of a smaller proteolytic derivative.

Tebbenkamp AT, Green C, Xu G, Denovan-Wright EM, Rising AC, Fromholt SE, Brown HH, Swing D, Mandel RJ, Tessarollo L, Borchelt DR. Tebbenkamp AT, et al. Hum Mol Genet. 2011 Jul 15;20(14):2770-82. doi: 10.1093/hmg/ddr176. Epub 2011 Apr 22. Hum Mol Genet. 2011. PMID: 21515588 Free PMC article.

3

Reduction of low-density lipoprotein receptor-related protein (LRP1) in hippocampal neurons does not proportionately reduce, or otherwise alter, amyloid deposition in APPswe/PS1dE9 transgenic mice.

Xu G, Green CC, Fromholt SE, Borchelt DR. Xu G, et al. Alzheimers Res Ther. 2012 Apr 26;4(2):12. doi: 10.1186/alzrt110. eCollection 2012. Alzheimers Res Ther. 2012. PMID: 22537779 Free PMC article.

4

Reversible pathologic and cognitive phenotypes in an inducible model of Alzheimer-amyloidosis.

Melnikova T, Fromholt S, Kim H, Lee D, Xu G, Price A, Moore BD, Golde TE, Felsenstein KM, Savonenko A, Borchelt DR. Melnikova T, et al. Among authors: fromholt s. J Neurosci. 2013 Feb 27;33(9):3765-79. doi: 10.1523/JNEUROSCI.4251-12.2013. J Neurosci. 2013. PMID: 23447589 Free PMC article.

5

Distinctive features of the D101N and D101G variants of superoxide dismutase 1; two mutations that produce rapidly progressing motor neuron disease.

Ayers J, Lelie H, Workman A, Prudencio M, Brown H, Fromholt S, Valentine J, Whitelegge J, Borchelt D. Ayers J, et al. Among authors: fromholt s. J Neurochem. 2014 Jan;128(2):305-14. doi: 10.1111/jnc.12451. Epub 2013 Oct 21. J Neurochem. 2014. PMID: 24032979 Free PMC article.

6

Experimental mutagenesis of huntingtin to map cleavage sites: different outcomes in cell and mouse models.

Tebbenkamp AT, Xu G, Siemienski ZB, Janus C, Fromholt SE, Brown HH, Swing D, Tessarollo L, Borchelt DR. Tebbenkamp AT, et al. J Huntingtons Dis. 2014;3(1):73-86. doi: 10.3233/JHD-130087. J Huntingtons Dis. 2014. PMID: 25062766

7

Widespread and efficient transduction of spinal cord and brain following neonatal AAV injection and potential disease modifying effect in ALS mice.

Ayers JI, Fromholt S, Sinyavskaya O, Siemienski Z, Rosario AM, Li A, Crosby KW, Cruz PE, DiNunno NM, Janus C, Ceballos-Diaz C, Borchelt DR, Golde TE, Chakrabarty P, Levites Y. Ayers JI, et al. Among authors: fromholt s. Mol Ther. 2015 Jan;23(1):53-62. doi: 10.1038/mt.2014.180. Epub 2014 Sep 17. Mol Ther. 2015. PMID: 25228069 Free PMC article.

8

Experimental transmissibility of mutant SOD1 motor neuron disease.

Ayers JI, Fromholt S, Koch M, DeBosier A, McMahon B, Xu G, Borchelt DR. Ayers JI, et al. Among authors: fromholt s. Acta Neuropathol. 2014 Dec;128(6):791-803. doi: 10.1007/s00401-014-1342-7. Epub 2014 Sep 28. Acta Neuropathol. 2014. PMID: 25262000

9

Direct and indirect mechanisms for wild-type SOD1 to enhance the toxicity of mutant SOD1 in bigenic transgenic mice.

Xu G, Ayers JI, Roberts BL, Brown H, Fromholt S, Green C, Borchelt DR. Xu G, et al. Among authors: fromholt s. Hum Mol Genet. 2015 Feb 15;24(4):1019-35. doi: 10.1093/hmg/ddu517. Epub 2014 Oct 9. Hum Mol Genet. 2015. PMID: 25305079 Free PMC article.

10

Substantially elevating the levels of αB-crystallin in spinal motor neurons of mutant SOD1 mice does not significantly delay paralysis or attenuate mutant protein aggregation.

Xu G, Fromholt S, Ayers JI, Brown H, Siemienski Z, Crosby KW, Mayer CA, Janus C, Borchelt DR. Xu G, et al. Among authors: fromholt s. J Neurochem. 2015 May;133(3):452-64. doi: 10.1111/jnc.13022. Epub 2015 Jan 26. J Neurochem. 2015. PMID: 25557022 Free PMC article.

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