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Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursor.
Cosmi L, De Palma R, Santarlasci V, Maggi L, Capone M, Frosali F, Rodolico G, Querci V, Abbate G, Angeli R, Berrino L, Fambrini M, Caproni M, Tonelli F, Lazzeri E, Parronchi P, Liotta F, Maggi E, Romagnani S, Annunziato F. Cosmi L, et al. Among authors: frosali f. J Exp Med. 2008 Aug 4;205(8):1903-16. doi: 10.1084/jem.20080397. Epub 2008 Jul 28. J Exp Med. 2008. PMID: 18663128 Free PMC article.
Phenotypic and functional features of human Th17 cells.
Annunziato F, Cosmi L, Santarlasci V, Maggi L, Liotta F, Mazzinghi B, Parente E, Filì L, Ferri S, Frosali F, Giudici F, Romagnani P, Parronchi P, Tonelli F, Maggi E, Romagnani S. Annunziato F, et al. Among authors: frosali f. J Exp Med. 2007 Aug 6;204(8):1849-61. doi: 10.1084/jem.20070663. Epub 2007 Jul 16. J Exp Med. 2007. PMID: 17635957 Free PMC article.
CD161 is a marker of all human IL-17-producing T-cell subsets and is induced by RORC.
Maggi L, Santarlasci V, Capone M, Peired A, Frosali F, Crome SQ, Querci V, Fambrini M, Liotta F, Levings MK, Maggi E, Cosmi L, Romagnani S, Annunziato F. Maggi L, et al. Among authors: frosali f. Eur J Immunol. 2010 Aug;40(8):2174-81. doi: 10.1002/eji.200940257. Eur J Immunol. 2010. PMID: 20486123 Free article.
Evidence of the transient nature of the Th17 phenotype of CD4+CD161+ T cells in the synovial fluid of patients with juvenile idiopathic arthritis.
Cosmi L, Cimaz R, Maggi L, Santarlasci V, Capone M, Borriello F, Frosali F, Querci V, Simonini G, Barra G, Piccinni MP, Liotta F, De Palma R, Maggi E, Romagnani S, Annunziato F. Cosmi L, et al. Among authors: frosali f. Arthritis Rheum. 2011 Aug;63(8):2504-15. doi: 10.1002/art.30332. Arthritis Rheum. 2011. PMID: 21381000 Free article.
Sublingual immunotherapy with Dermatophagoides monomeric allergoid down-regulates allergen-specific immunoglobulin E and increases both interferon-gamma- and interleukin-10-production.
Cosmi L, Santarlasci V, Angeli R, Liotta F, Maggi L, Frosali F, Rossi O, Falagiani P, Riva G, Romagnani S, Annunziato F, Maggi E. Cosmi L, et al. Among authors: frosali f. Clin Exp Allergy. 2006 Mar;36(3):261-72. doi: 10.1111/j.1365-2222.2006.02429.x. Clin Exp Allergy. 2006. PMID: 16499636 Clinical Trial.
CD14+CD34low cells with stem cell phenotypic and functional features are the major source of circulating endothelial progenitors.
Romagnani P, Annunziato F, Liotta F, Lazzeri E, Mazzinghi B, Frosali F, Cosmi L, Maggi L, Lasagni L, Scheffold A, Kruger M, Dimmeler S, Marra F, Gensini G, Maggi E, Romagnani S. Romagnani P, et al. Among authors: frosali f. Circ Res. 2005 Aug 19;97(4):314-22. doi: 10.1161/01.RES.0000177670.72216.9b. Epub 2005 Jul 14. Circ Res. 2005. PMID: 16020753
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