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MYC Controls the Epstein-Barr Virus Lytic Switch.
Guo R, Jiang C, Zhang Y, Govande A, Trudeau SJ, Chen F, Fry CJ, Puri R, Wolinsky E, Schineller M, Frost TC, Gebre M, Zhao B, Giulino-Roth L, Doench JG, Teng M, Gewurz BE. Guo R, et al. Among authors: frost tc. Mol Cell. 2020 May 21;78(4):653-669.e8. doi: 10.1016/j.molcel.2020.03.025. Epub 2020 Apr 20. Mol Cell. 2020. PMID: 32315601 Free PMC article.
Reversal of viral and epigenetic HLA class I repression in Merkel cell carcinoma.
Lee PC, Klaeger S, Le PM, Korthauer K, Cheng J, Ananthapadmanabhan V, Frost TC, Stevens JD, Wong AY, Iorgulescu JB, Tarren AY, Chea VA, Carulli IP, Lemvigh CK, Pedersen CB, Gartin AK, Sarkizova S, Wright KT, Li LW, Nomburg J, Li S, Huang T, Liu X, Pomerance L, Doherty LM, Apffel AM, Wallace LJ, Rachimi S, Felt KD, Wolff JO, Witten E, Zhang W, Neuberg D, Lane WJ, Zhang G, Olsen LR, Thakuria M, Rodig SJ, Clauser KR, Starrett GJ, Doench JG, Buhrlage SJ, Carr SA, DeCaprio JA, Wu CJ, Keskin DB. Lee PC, et al. Among authors: frost tc. J Clin Invest. 2022 Jul 1;132(13):e151666. doi: 10.1172/JCI151666. J Clin Invest. 2022. PMID: 35775490 Free PMC article.
Addiction of Merkel cell carcinoma to MUC1-C identifies a potential new target for treatment.
Morimoto Y, Fushimi A, Yamashita N, Hagiwara M, Bhattacharya A, Cheng J, Frost TC, Ahmad R, Daimon T, Huang L, Hata T, Takahashi H, Yamamoto M, Suzuki Y, DeCaprio JA, Kufe D. Morimoto Y, et al. Among authors: frost tc. Oncogene. 2022 Jul;41(27):3511-3523. doi: 10.1038/s41388-022-02361-3. Epub 2022 Jun 10. Oncogene. 2022. PMID: 35688945 Free PMC article.
Milademetan is a highly potent MDM2 inhibitor in Merkel cell carcinoma.
Ananthapadmanabhan V, Frost TC, Soroko KM, Knott A, Magliozzi BJ, Gokhale PC, Tirunagaru VG, Doebele RC, DeCaprio JA. Ananthapadmanabhan V, et al. Among authors: frost tc. JCI Insight. 2022 Jul 8;7(13):e160513. doi: 10.1172/jci.insight.160513. JCI Insight. 2022. PMID: 35801592 Free PMC article.