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2007 1
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2012 3
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2020 1
2022 1
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Page 1
Large-scale sequencing identifies multiple genes and rare variants associated with Crohn's disease susceptibility.
Sazonovs A, Stevens CR, Venkataraman GR, Yuan K, Avila B, Abreu MT, Ahmad T, Allez M, Ananthakrishnan AN, Atzmon G, Baras A, Barrett JC, Barzilai N, Beaugerie L, Beecham A, Bernstein CN, Bitton A, Bokemeyer B, Chan A, Chung D, Cleynen I, Cosnes J, Cutler DJ, Daly A, Damas OM, Datta LW, Dawany N, Devoto M, Dodge S, Ellinghaus E, Fachal L, Farkkila M, Faubion W, Ferreira M, Franchimont D, Gabriel SB, Ge T, Georges M, Gettler K, Giri M, Glaser B, Goerg S, Goyette P, Graham D, Hämäläinen E, Haritunians T, Heap GA, Hiltunen M, Hoeppner M, Horowitz JE, Irving P, Iyer V, Jalas C, Kelsen J, Khalili H, Kirschner BS, Kontula K, Koskela JT, Kugathasan S, Kupcinskas J, Lamb CA, Laudes M, Lévesque C, Levine AP, Lewis JD, Liefferinckx C, Loescher BS, Louis E, Mansfield J, May S, McCauley JL, Mengesha E, Mni M, Moayyedi P, Moran CJ, Newberry RD, O'Charoen S, Okou DT, Oldenburg B, Ostrer H, Palotie A, Paquette J, Pekow J, Peter I, Pierik MJ, Ponsioen CY, Pontikos N, Prescott N, Pulver AE, Rahmouni S, Rice DL, Saavalainen P, Sands B, Sartor RB, Schiff ER, Schreiber S, Schumm LP, Segal AW, Seksik P, Shawky R, Sheikh SZ, Silverberg MS, Simmons A, Skeiceviciene J, Sokol H, Solomonson M, Somine… See abstract for full author list ➔ Sazonovs A, et al. Among authors: atzmon g. Nat Genet. 2022 Sep;54(9):1275-1283. doi: 10.1038/s41588-022-01156-2. Epub 2022 Aug 29. Nat Genet. 2022. PMID: 36038634 Free PMC article.
Genetics, lifestyle and longevity: Lessons from centenarians.
Govindaraju D, Atzmon G, Barzilai N. Govindaraju D, et al. Among authors: atzmon g. Appl Transl Genom. 2015 Feb 4;4:23-32. doi: 10.1016/j.atg.2015.01.001. eCollection 2015 Mar. Appl Transl Genom. 2015. PMID: 26937346 Free PMC article. Review.
Gene size matters.
Mirina A, Atzmon G, Ye K, Bergman A. Mirina A, et al. Among authors: atzmon g. PLoS One. 2012;7(11):e49093. doi: 10.1371/journal.pone.0049093. Epub 2012 Nov 9. PLoS One. 2012. PMID: 23152854 Free PMC article.
Thus, we state here that there is a need for correction for such bias when performing downstream gene-level analysis, e.g. pathway analysis and gene-set analysis. We investigate several methods of obtaining gene level statistical significance in GWAS, and compare their eff …
Thus, we state here that there is a need for correction for such bias when performing downstream gene-level analysis, e.g. pathway an …
The effects of environmental stressors on candidate aging associated genes.
Andrawus M, Sharvit L, Shekhidem HA, Roichman A, Cohen HY, Atzmon G. Andrawus M, et al. Among authors: atzmon g. Exp Gerontol. 2020 Aug;137:110952. doi: 10.1016/j.exger.2020.110952. Epub 2020 Apr 25. Exp Gerontol. 2020. PMID: 32344118
Aging may occur at different rates between and within species, especially or (it varies) among the long-lived ones. Here, we ask whether this diversity (e.g. aging phenotype) stems from genetic or environmental factors or as a combination between the two (epigenetics). ...
Aging may occur at different rates between and within species, especially or (it varies) among the long-lived ones. Here, we ask whether thi …
Evaluating the contribution of rare variants to type 2 diabetes and related traits using pedigrees.
Jun G, Manning A, Almeida M, Zawistowski M, Wood AR, Teslovich TM, Fuchsberger C, Feng S, Cingolani P, Gaulton KJ, Dyer T, Blackwell TW, Chen H, Chines PS, Choi S, Churchhouse C, Fontanillas P, King R, Lee S, Lincoln SE, Trubetskoy V, DePristo M, Fingerlin T, Grossman R, Grundstad J, Heath A, Kim J, Kim YJ, Laramie J, Lee J, Li H, Liu X, Livne O, Locke AE, Maller J, Mazur A, Morris AP, Pollin TI, Ragona D, Reich D, Rivas MA, Scott LJ, Sim X, Tearle RG, Teo YY, Williams AL, Zöllner S, Curran JE, Peralta J, Akolkar B, Bell GI, Burtt NP, Cox NJ, Florez JC, Hanis CL, McKeon C, Mohlke KL, Seielstad M, Wilson JG, Atzmon G, Below JE, Dupuis J, Nicolae DL, Lehman D, Park T, Won S, Sladek R, Altshuler D, McCarthy MI, Duggirala R, Boehnke M, Frayling TM, Abecasis GR, Blangero J. Jun G, et al. Among authors: atzmon g. Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):379-384. doi: 10.1073/pnas.1705859115. Epub 2017 Dec 26. Proc Natl Acad Sci U S A. 2018. PMID: 29279374 Free PMC article.
A Human Variant of Glucose-Regulated Protein 94 That Inefficiently Supports IGF Production.
Marzec M, Hawkes CP, Eletto D, Boyle S, Rosenfeld R, Hwa V, Wit JM, van Duyvenvoorde HA, Oostdijk W, Losekoot M, Pedersen O, Yeap BB, Flicker L, Barzilai N, Atzmon G, Grimberg A, Argon Y. Marzec M, et al. Among authors: atzmon g. Endocrinology. 2016 May;157(5):1914-28. doi: 10.1210/en.2015-2058. Epub 2016 Mar 16. Endocrinology. 2016. PMID: 26982636 Free PMC article.
Human longevity and common variations in the LMNA gene: a meta-analysis.
Conneely KN, Capell BC, Erdos MR, Sebastiani P, Solovieff N, Swift AJ, Baldwin CT, Budagov T, Barzilai N, Atzmon G, Puca AA, Perls TT, Geesaman BJ, Boehnke M, Collins FS. Conneely KN, et al. Among authors: atzmon g. Aging Cell. 2012 Jun;11(3):475-81. doi: 10.1111/j.1474-9726.2012.00808.x. Epub 2012 Mar 27. Aging Cell. 2012. PMID: 22340368 Free PMC article.
Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms.
Horikoshi M, Pasquali L, Wiltshire S, Huyghe JR, Mahajan A, Asimit JL, Ferreira T, Locke AE, Robertson NR, Wang X, Sim X, Fujita H, Hara K, Young R, Zhang W, Choi S, Chen H, Kaur I, Takeuchi F, Fontanillas P, Thuillier D, Yengo L, Below JE, Tam CH, Wu Y, Abecasis G, Altshuler D, Bell GI, Blangero J, Burtt NP, Duggirala R, Florez JC, Hanis CL, Seielstad M, Atzmon G, Chan JC, Ma RC, Froguel P, Wilson JG, Bharadwaj D, Dupuis J, Meigs JB, Cho YS, Park T, Kooner JS, Chambers JC, Saleheen D, Kadowaki T, Tai ES, Mohlke KL, Cox NJ, Ferrer J, Zeggini E, Kato N, Teo YY, Boehnke M, McCarthy MI, Morris AP; T2D-GENES Consortium. Horikoshi M, et al. Among authors: atzmon g. Hum Mol Genet. 2016 May 15;25(10):2070-2081. doi: 10.1093/hmg/ddw048. Epub 2016 Feb 23. Hum Mol Genet. 2016. PMID: 26911676 Free PMC article.
Cancer risks in the Druze Isifya Village: Reasons and RF/MW antennas.
Atzmon I, Linn S, Richter E, Portnov BA. Atzmon I, et al. Pathophysiology. 2012 Feb;19(1):21-8. doi: 10.1016/j.pathophys.2011.07.005. Epub 2011 Aug 27. Pathophysiology. 2012. PMID: 21873036 Free article.
The analysis was adjusted for measures of life style and occupational exposure, and Binary multiple logistic regressions was used, for all cancer sites and for individual cancer types for those cancers with at least 5 documented cases. RESULTS: Past occupational exposures to chem …
The analysis was adjusted for measures of life style and occupational exposure, and Binary multiple logistic regressions was used, for all c …
Genetic predisposition to elevated serum thyrotropin is associated with exceptional longevity.
Atzmon G, Barzilai N, Surks MI, Gabriely I. Atzmon G, et al. J Clin Endocrinol Metab. 2009 Dec;94(12):4768-75. doi: 10.1210/jc.2009-0808. Epub 2009 Oct 16. J Clin Endocrinol Metab. 2009. PMID: 19837933 Free PMC article.
Allele frequency of two SNPs in the promoter/enhancer region of TSHR gene, associated with increased serum TSH, was higher in centenarians and their offspring compared to controls (rs10149689 G allele frequency, 0.57 and 0.53 vs. 0.48; P = 0.001 and P = 0.08; odds ratio, 1 …
Allele frequency of two SNPs in the promoter/enhancer region of TSHR gene, associated with increased serum TSH, was higher in centenarians a …
11 results