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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1983 1
1984 1
1985 1
1987 1
1989 3
1990 3
1991 4
1993 5
1994 2
1995 6
1996 10
1997 11
1998 20
1999 22
2000 16
2001 14
2002 33
2003 46
2004 45
2005 61
2006 71
2007 97
2008 114
2009 142
2010 171
2011 191
2012 233
2013 254
2014 306
2015 353
2016 369
2017 373
2018 482
2019 567
2020 592
2021 740
2022 862
2023 895
2024 347

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6,544 results

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Page 1
TRIM28 promotes the escape of gastric cancer cells from immune surveillance by increasing PD-L1 abundance.
Ma X, Jia S, Wang G, Liang M, Guo T, Du H, Li S, Li X, Huangfu L, Guo J, Xing X, Ji J. Ma X, et al. Among authors: jia s. Signal Transduct Target Ther. 2023 Jun 26;8(1):246. doi: 10.1038/s41392-023-01450-3. Signal Transduct Target Ther. 2023. PMID: 37357254 Free PMC article.
It was found that TRIM28 was positively correlated with PD-L1 in G.C. cells. Moreover, high TRIM28 expression suggests poor survival in a cohort of 466 patients with G.C., and this observation is consistent while analyzing data from publicly available databases. ... …
It was found that TRIM28 was positively correlated with PD-L1 in G.C. cells. Moreover, high TRIM28 expression suggests poor survival …
Interaction between HLA-G and NK cell receptor KIR2DL4 orchestrates HER2-positive breast cancer resistance to trastuzumab.
Zheng G, Guo Z, Li W, Xi W, Zuo B, Zhang R, Wen W, Yang AG, Jia L. Zheng G, et al. Among authors: jia l. Signal Transduct Target Ther. 2021 Jun 23;6(1):236. doi: 10.1038/s41392-021-00629-w. Signal Transduct Target Ther. 2021. PMID: 34158475 Free PMC article.
Here, we found that the nonclassical histocompatibility antigen HLA-G desensitizes breast cancer cells to trastuzumab by binding to the natural killer (NK) cell receptor KIR2DL4. ...Blockade of HLA-G/KIR2DL4 signaling improved the vulnerability of HER2-positive brea …
Here, we found that the nonclassical histocompatibility antigen HLA-G desensitizes breast cancer cells to trastuzumab by binding to t …
Multi-omics reveals 2-bromo-4,6-dinitroaniline (BDNA)-induced hepatotoxicity and the role of the gut-liver axis in rats.
Deng F, Qin G, Chen Y, Zhang X, Zhu M, Hou M, Yao Q, Gu W, Wang C, Yang H, Jia X, Wu C, Peng H, Du H, Tang S. Deng F, et al. Among authors: jia x. J Hazard Mater. 2023 Sep 5;457:131760. doi: 10.1016/j.jhazmat.2023.131760. Epub 2023 Jun 3. J Hazard Mater. 2023. PMID: 37285786
After 28 days of oral administration, compared with the control group, 100 mg/kg BDNA significantly triggered hepatotoxicity, upregulated toxicity indicators (e.g., HSI, ALT, and ARG1), and induced systemic inflammation (e.g., G-CSF, MIP-2, RANTES, and VEGF), …
After 28 days of oral administration, compared with the control group, 100 mg/kg BDNA significantly triggered hepatotoxicity, upregulated to …
Gut microbiota regulates postprandial GLP-1 response via ileal bile acid-TGR5 signaling.
Wang Q, Lin H, Shen C, Zhang M, Wang X, Yuan M, Yuan M, Jia S, Cao Z, Wu C, Chen B, Gao A, Bi Y, Ning G, Wang W, Wang J, Liu R. Wang Q, et al. Among authors: jia s. Gut Microbes. 2023 Dec;15(2):2274124. doi: 10.1080/19490976.2023.2274124. Epub 2023 Nov 9. Gut Microbes. 2023. PMID: 37942583 Free PMC article.
Microbiome depletion did not influence the GLP-1 secretory function of primary ileal cells in response to stimulators in vitro, but dramatically changed the postprandial dynamics of endogenous bile acids, particularly omega-muricholic acid (omegaMCA) and hyocholic acid (HCA). The …
Microbiome depletion did not influence the GLP-1 secretory function of primary ileal cells in response to stimulators in vitro, but dramatic …
Single hormone or synthetic agonist induces G(s)/G(i) coupling selectivity of EP receptors via distinct binding modes and propagating paths.
Huang SM, Xiong MY, Liu L, Mu J, Wang MW, Jia YL, Cai K, Tie L, Zhang C, Cao S, Wen X, Wang JL, Guo SC, Li Y, Qu CX, He QT, Cai BY, Xue C, Gan S, Xie Y, Cong X, Yang Z, Kong W, Li S, Li Z, Xiao P, Yang F, Yu X, Guan YF, Zhang X, Liu Z, Yang BX, Du Y, Sun JP. Huang SM, et al. Among authors: jia yl. Proc Natl Acad Sci U S A. 2023 Jul 25;120(30):e2216329120. doi: 10.1073/pnas.2216329120. Epub 2023 Jul 21. Proc Natl Acad Sci U S A. 2023. PMID: 37478163 Free PMC article.
Notably, by solving Cryo-electron microscope (cryo-EM) structures of EP3-G(i), EP4-G(s), and EP4-G(i) in complex with endogenous prostaglandin E(2) (PGE(2))or two synthetic agonists and comparing with PGE(2)-EP2-G(s) structures, we found that unique pr …
Notably, by solving Cryo-electron microscope (cryo-EM) structures of EP3-G(i), EP4-G(s), and EP4-G(i) in complex with e …
Roles of HLA-G/KIR2DL4 in Breast Cancer Immune Microenvironment.
Zheng G, Jia L, Yang AG. Zheng G, et al. Among authors: jia l. Front Immunol. 2022 Feb 3;13:791975. doi: 10.3389/fimmu.2022.791975. eCollection 2022. Front Immunol. 2022. PMID: 35185887 Free PMC article. Review.
Our previous study had shown that HLA-G was a pivotal mediator of breast cancer resistance to trastuzumab, and blockade of the HLA-G/KIR2DL4 interaction can resensitize breast cancer to trastuzumab treatment. ...In addition, it is also necessary to unravel the mecha …
Our previous study had shown that HLA-G was a pivotal mediator of breast cancer resistance to trastuzumab, and blockade of the HLA- …
Dupilumab: Advances in the off-label usage of IL4/IL13 antagonist in dermatoses.
Jia F, Zhao Q, Shi P, Liu H, Zhang F. Jia F, et al. Dermatol Ther. 2022 Dec;35(12):e15924. doi: 10.1111/dth.15924. Epub 2022 Oct 20. Dermatol Ther. 2022. PMID: 36219538 Review.
Th1/Th2 ratio, also referred as Th1/Th2 balance, represent the T lymphocytes immune pattern to a certain degree: Th1-dominated responses are often involved in intracellular infections (e.g., mycobacterium tuberculosis) and autoimmune diseases (e.g., Graves' disease) …
Th1/Th2 ratio, also referred as Th1/Th2 balance, represent the T lymphocytes immune pattern to a certain degree: Th1-dominated responses are …
The potential interplay between G-quadruplex and p53: their roles in regulation of ferroptosis in cancer.
Zhang L, Lu Y, Ma X, Xing Y, Sun J, Jia Y. Zhang L, et al. Among authors: jia y. Front Mol Biosci. 2022 Jul 25;9:965924. doi: 10.3389/fmolb.2022.965924. eCollection 2022. Front Mol Biosci. 2022. PMID: 35959461 Free PMC article. Review.
Investigation of G-quadruplexes is thus vital to revealing their biological functions. Specific G-quadruplexes are investigated to discover new effective anticancer drugs. ...
Investigation of G-quadruplexes is thus vital to revealing their biological functions. Specific G-quadruplexes are investigate …
Deciphering the tumor-suppressive role of PSMB9 in melanoma through multi-omics and single-cell transcriptome analyses.
Hu X, Hu Z, Zhang H, Zhang N, Feng H, Jia X, Zhang C, Cheng Q. Hu X, et al. Among authors: jia x. Cancer Lett. 2024 Jan 28;581:216466. doi: 10.1016/j.canlet.2023.216466. Epub 2023 Nov 8. Cancer Lett. 2024. PMID: 37944578
Epigenetic modifications orchestrated by DNA methylation contributed to tumorigenesis, thus potentially unveiling melanoma prognosis. Here, we identified an interferon-gamma (IFN-g) sensitive subtype, which possesses favorable outcomes, robust infiltration CD8+T cells, and …
Epigenetic modifications orchestrated by DNA methylation contributed to tumorigenesis, thus potentially unveiling melanoma prognosis. Here, …
Scavenger receptor a mediates glycated LDL transcytosis across endothelial cells to promote atherosclerosis.
Cheng W, Shu M, Kuang L, Bai X, Jia X, Zhao Y, Lu Y, Zhu L, Wang L, Zhu Y, Shu Y, Song Y, Jin S. Cheng W, et al. Among authors: jia x. Int J Biol Macromol. 2023 Apr 30;235:123836. doi: 10.1016/j.ijbiomac.2023.123836. Epub 2023 Feb 25. Int J Biol Macromol. 2023. PMID: 36849072 Free article.
In vitro, we evaluated the uptake and transcytosis rates of N-LDL and G-LDL in endothelial cells and the uptake and transcytosis rates of G-LDL were much higher than those of N-LDL. ...In vivo, G-LDL was injected in the tail vein of ApoE(-/-) mice to investig …
In vitro, we evaluated the uptake and transcytosis rates of N-LDL and G-LDL in endothelial cells and the uptake and transcytosis rate …
6,544 results