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Epigenetic silencing of the tumor suppressor microRNA Hsa-miR-124a regulates CDK6 expression and confers a poor prognosis in acute lymphoblastic leukemia.
Agirre X, Vilas-Zornoza A, Jiménez-Velasco A, Martin-Subero JI, Cordeu L, Gárate L, San José-Eneriz E, Abizanda G, Rodríguez-Otero P, Fortes P, Rifón J, Bandrés E, Calasanz MJ, Martín V, Heiniger A, Torres A, Siebert R, Román-Gomez J, Prósper F. Agirre X, et al. Among authors: garate l. Cancer Res. 2009 May 15;69(10):4443-53. doi: 10.1158/0008-5472.CAN-08-4025. Epub 2009 May 12. Cancer Res. 2009. PMID: 19435910 Free article.
Promoter hypomethylation of the LINE-1 retrotransposable elements activates sense/antisense transcription and marks the progression of chronic myeloid leukemia.
Roman-Gomez J, Jimenez-Velasco A, Agirre X, Cervantes F, Sanchez J, Garate L, Barrios M, Castillejo JA, Navarro G, Colomer D, Prosper F, Heiniger A, Torres A. Roman-Gomez J, et al. Among authors: garate l. Oncogene. 2005 Nov 3;24(48):7213-23. doi: 10.1038/sj.onc.1208866. Oncogene. 2005. PMID: 16170379 Free article. Retracted.
Abnormal methylation of the common PARK2 and PACRG promoter is associated with downregulation of gene expression in acute lymphoblastic leukemia and chronic myeloid leukemia.
Agirre X, Román-Gómez J, Vázquez I, Jiménez-Velasco A, Garate L, Montiel-Duarte C, Artieda P, Cordeu L, Lahortiga I, Calasanz MJ, Heiniger A, Torres A, Minna JD, Prósper F. Agirre X, et al. Among authors: garate l. Int J Cancer. 2006 Apr 15;118(8):1945-53. doi: 10.1002/ijc.21584. Int J Cancer. 2006. PMID: 16287063 Free article.
Promoter hypermethylation and global hypomethylation are independent epigenetic events in lymphoid leukemogenesis with opposing effects on clinical outcome.
Roman-Gomez J, Jimenez-Velasco A, Agirre X, Castillejo JA, Navarro G, Garate L, Jose-Eneriz ES, Cordeu L, Barrios M, Prosper F, Heiniger A, Torres A. Roman-Gomez J, et al. Among authors: garate l. Leukemia. 2006 Aug;20(8):1445-8. doi: 10.1038/sj.leu.2404257. Epub 2006 May 11. Leukemia. 2006. PMID: 16688225 No abstract available.
Epigenetic regulation of Wnt-signaling pathway in acute lymphoblastic leukemia.
Román-Gómez J, Cordeu L, Agirre X, Jiménez-Velasco A, San José-Eneriz E, Garate L, Calasanz MJ, Heiniger A, Torres A, Prosper F. Román-Gómez J, et al. Among authors: garate l. Blood. 2007 Apr 15;109(8):3462-9. doi: 10.1182/blood-2006-09-047043. Epub 2006 Dec 5. Blood. 2007. PMID: 17148581 Free article. Retracted. Clinical Trial.
Epigenetic regulation of PRAME gene in chronic myeloid leukemia.
Roman-Gomez J, Jimenez-Velasco A, Agirre X, Castillejo JA, Navarro G, Jose-Eneriz ES, Garate L, Cordeu L, Cervantes F, Prosper F, Heiniger A, Torres A. Roman-Gomez J, et al. Among authors: garate l. Leuk Res. 2007 Nov;31(11):1521-8. doi: 10.1016/j.leukres.2007.02.016. Epub 2007 Mar 26. Leuk Res. 2007. PMID: 17382387
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