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Page 1
Identification of a dynamic core transcriptional network in t(8;21) AML that regulates differentiation block and self-renewal.
Ptasinska A, Assi SA, Martinez-Soria N, Imperato MR, Piper J, Cauchy P, Pickin A, James SR, Hoogenkamp M, Williamson D, Wu M, Tenen DG, Ott S, Westhead DR, Cockerill PN, Heidenreich O, Bonifer C. Ptasinska A, et al. Cell Rep. 2014 Sep 25;8(6):1974-1988. doi: 10.1016/j.celrep.2014.08.024. Epub 2014 Sep 18. Cell Rep. 2014. PMID: 25242324 Free PMC article.
RUNX1 reshapes the epigenetic landscape at the onset of haematopoiesis.
Lichtinger M, Ingram R, Hannah R, Müller D, Clarke D, Assi SA, Lie-A-Ling M, Noailles L, Vijayabaskar MS, Wu M, Tenen DG, Westhead DR, Kouskoff V, Lacaud G, Göttgens B, Bonifer C. Lichtinger M, et al. EMBO J. 2012 Nov 14;31(22):4318-33. doi: 10.1038/emboj.2012.275. Epub 2012 Oct 12. EMBO J. 2012. PMID: 23064151 Free PMC article.
Depletion of RUNX1/ETO in t(8;21) AML cells leads to genome-wide changes in chromatin structure and transcription factor binding.
Ptasinska A, Assi SA, Mannari D, James SR, Williamson D, Dunne J, Hoogenkamp M, Wu M, Care M, McNeill H, Cauchy P, Cullen M, Tooze RM, Tenen DG, Young BD, Cockerill PN, Westhead DR, Heidenreich O, Bonifer C. Ptasinska A, et al. Leukemia. 2012 Aug;26(8):1829-41. doi: 10.1038/leu.2012.49. Epub 2012 Feb 20. Leukemia. 2012. PMID: 22343733 Free PMC article.
Two distinct auto-regulatory loops operate at the PU.1 locus in B cells and myeloid cells.
Leddin M, Perrod C, Hoogenkamp M, Ghani S, Assi S, Heinz S, Wilson NK, Follows G, Schönheit J, Vockentanz L, Mosammam AM, Chen W, Tenen DG, Westhead DR, Göttgens B, Bonifer C, Rosenbauer F. Leddin M, et al. Blood. 2011 Mar 10;117(10):2827-38. doi: 10.1182/blood-2010-08-302976. Epub 2011 Jan 14. Blood. 2011. PMID: 21239694 Free PMC article.