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Page 1
IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein.
Gaggero S, Martinez-Fabregas J, Cozzani A, Fyfe PK, Leprohon M, Yang J, Thomasen FE, Winkelmann H, Magnez R, Conti AG, Wilmes S, Pohler E, van Gijsel Bonnello M, Thuru X, Quesnel B, Soncin F, Piehler J, Lindorff-Larsen K, Roychoudhuri R, Moraga I, Mitra S. Gaggero S, et al. Sci Immunol. 2022 Dec 9;7(78):eade5686. doi: 10.1126/sciimmunol.ade5686. Epub 2022 Dec 2. Sci Immunol. 2022. PMID: 36459543
A potential role of preexisting inflammation in the development of acute myelopathy following CAR T-cell therapy for diffuse large B-cell lymphoma.
Beauvais D, Cozzani A, Blaise AS, Moreau AS, Varlet P, Gaggero S, Alidjinou EK, Vannod-Michel Q, Morschhauser F, Labalette M, Yakoub-Agha I, Mitra S. Beauvais D, et al. Among authors: gaggero s. Curr Res Transl Med. 2022 May;70(2):103331. doi: 10.1016/j.retram.2021.103331. Epub 2022 Jan 6. Curr Res Transl Med. 2022. PMID: 34999480
Genomic profiling of Mycosis Fungoides identifies patients at high risk of disease progression.
Fléchon L, Arib I, Dutta AK, Hasan Bou Issa L, Sklavenitis-Pistofidis R, Tilmont R, Stewart C, Dubois R, Poulain S, Copin MC, Javed S, Nudel M, Cavalieri D, Escure G, Gower N, Chauvet P, Gazeau N, Saade C, Thiam MB, Ouelkite-Oumouchal A, Gaggero S, Cailliau É, Faiz S, Carpentier O, Duployez N, Idziorek TB, Mortier L, Figeac M, Preudhomme C, Quesnel B, Mitra S, Morschhauser F, Getz G, Ghobrial IM, Manier S. Fléchon L, et al. Among authors: gaggero s. Blood Adv. 2024 Mar 21:bloodadvances.2023012125. doi: 10.1182/bloodadvances.2023012125. Online ahead of print. Blood Adv. 2024. PMID: 38513135
MYC dependency in GLS1 and NAMPT is a therapeutic vulnerability in multiple myeloma.
Hasan Bou Issa L, Fléchon L, Laine W, Ouelkdite A, Gaggero S, Cozzani A, Tilmont R, Chauvet P, Gower N, Sklavenitis-Pistofidis R, Brinster C, Thuru X, Touil Y, Quesnel B, Mitra S, Ghobrial IM, Kluza J, Manier S. Hasan Bou Issa L, et al. Among authors: gaggero s. iScience. 2024 Mar 4;27(4):109417. doi: 10.1016/j.isci.2024.109417. eCollection 2024 Apr 19. iScience. 2024. PMID: 38510131 Free PMC article.
NFAT5 Amplifies Antipathogen Responses by Enhancing Chromatin Accessibility, H3K27 Demethylation, and Transcription Factor Recruitment.
Lunazzi G, Buxadé M, Riera-Borrull M, Higuera L, Bonnin S, Huerga Encabo H, Gaggero S, Reyes-Garau D, Company C, Cozzuto L, Ponomarenko J, Aramburu J, López-Rodríguez C. Lunazzi G, et al. Among authors: gaggero s. J Immunol. 2021 Jun 1;206(11):2652-2667. doi: 10.4049/jimmunol.2000624. Epub 2021 May 24. J Immunol. 2021. PMID: 34031145 Free PMC article.
Nidogen-1 is a novel extracellular ligand for the NKp44 activating receptor.
Gaggero S, Bruschi M, Petretto A, Parodi M, Del Zotto G, Lavarello C, Prato C, Santucci L, Barbuto A, Bottino C, Candiano G, Moretta A, Vitale M, Moretta L, Cantoni C. Gaggero S, et al. Oncoimmunology. 2018 Jul 11;7(9):e1470730. doi: 10.1080/2162402X.2018.1470730. eCollection 2018. Oncoimmunology. 2018. PMID: 30228939 Free PMC article.