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Interleukin-6 (IL-6) and/or soluble IL-6 receptor down-regulation of human type II collagen gene expression in articular chondrocytes requires a decrease of Sp1.Sp3 ratio and of the binding activity of both factors to the COL2A1 promoter.
Porée B, Kypriotou M, Chadjichristos C, Beauchef G, Renard E, Legendre F, Melin M, Gueret S, Hartmann DJ, Malléin-Gerin F, Pujol JP, Boumediene K, Galéra P. Porée B, et al. Among authors: galera p. J Biol Chem. 2008 Feb 22;283(8):4850-65. doi: 10.1074/jbc.M706387200. Epub 2007 Dec 7. J Biol Chem. 2008. PMID: 18065760 Free article.
Asporin expression is highly regulated in human chondrocytes.
Duval E, Bigot N, Hervieu M, Kou I, Leclercq S, Galéra P, Boumediene K, Baugé C. Duval E, et al. Among authors: galera p. Mol Med. 2011;17(7-8):816-23. doi: 10.2119/molmed.2011.00052. Epub 2011 Apr 25. Mol Med. 2011. PMID: 21528154 Free PMC article.
The p65 subunit of NF-κB inhibits COL1A1 gene transcription in human dermal and scleroderma fibroblasts through its recruitment on promoter by protein interaction with transcriptional activators (c-Krox, Sp1, and Sp3).
Beauchef G, Bigot N, Kypriotou M, Renard E, Porée B, Widom R, Dompmartin-Blanchere A, Oddos T, Maquart FX, Demoor M, Boumediene K, Galera P. Beauchef G, et al. Among authors: galera p. J Biol Chem. 2012 Jan 27;287(5):3462-78. doi: 10.1074/jbc.M111.286443. Epub 2011 Dec 2. J Biol Chem. 2012. PMID: 22139845 Free PMC article.
Sox9/Sox6 and Sp1 are involved in the insulin-like growth factor-I-mediated upregulation of human type II collagen gene expression in articular chondrocytes.
Renard E, Porée B, Chadjichristos C, Kypriotou M, Maneix L, Bigot N, Legendre F, Ollitrault D, De Crombrugghe B, Malléin-Gérin F, Moslemi S, Demoor M, Boumediene K, Galéra P. Renard E, et al. Among authors: galera p. J Mol Med (Berl). 2012 Jun;90(6):649-66. doi: 10.1007/s00109-011-0842-3. Epub 2012 Jan 4. J Mol Med (Berl). 2012. PMID: 22215151
138 results