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Page 1
Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors.
Lloyd DJ, St Jean DJ Jr, Kurzeja RJ, Wahl RC, Michelsen K, Cupples R, Chen M, Wu J, Sivits G, Helmering J, Komorowski R, Ashton KS, Pennington LD, Fotsch C, Vazir M, Chen K, Chmait S, Zhang J, Liu L, Norman MH, Andrews KL, Bartberger MD, Van G, Galbreath EJ, Vonderfecht SL, Wang M, Jordan SR, Véniant MM, Hale C. Lloyd DJ, et al. Nature. 2013 Dec 19;504(7480):437-40. doi: 10.1038/nature12724. Epub 2013 Nov 13. Nature. 2013. PMID: 24226772
Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 2. Leveraging structure-based drug design to identify analogues with improved pharmacokinetic profiles.
St Jean DJ Jr, Ashton KS, Bartberger MD, Chen J, Chmait S, Cupples R, Galbreath E, Helmering J, Hong FT, Jordan SR, Liu L, Kunz RK, Michelsen K, Nishimura N, Pennington LD, Poon SF, Reid D, Sivits G, Stec MM, Tadesse S, Tamayo N, Van G, Yang KC, Zhang J, Norman MH, Fotsch C, Lloyd DJ, Hale C. St Jean DJ Jr, et al. Among authors: galbreath e. J Med Chem. 2014 Jan 23;57(2):325-38. doi: 10.1021/jm4016747. Epub 2014 Jan 9. J Med Chem. 2014. PMID: 24405213
Toxicologic Neuropathology of Novel Biotherapeutics.
Bangari DS, Lanigan LG, Cramer SD, Grieves JL, Meisner R, Rogers AB, Galbreath EJ, Bolon B. Bangari DS, et al. Among authors: galbreath ej. Toxicol Pathol. 2023 Oct;51(7-8):414-431. doi: 10.1177/01926233241230542. Epub 2024 Feb 21. Toxicol Pathol. 2023. PMID: 38380881
Scientific and Regulatory Policy Committee Technical Review: Biology and Pathology of Ganglia in Animal Species Used for Nonclinical Safety Testing.
Bennet BM, Pardo ID, Assaf BT, Buza E, Cramer SD, Crawford LK, Engelhardt JA, Galbreath EJ, Grubor B, Morrison JP, Osborne TS, Sharma AK, Bolon B. Bennet BM, et al. Among authors: galbreath ej. Toxicol Pathol. 2023 Jul;51(5):278-305. doi: 10.1177/01926233231213851. Toxicol Pathol. 2023. PMID: 38047294 Review.
Gene therapy for cross-correction of somatic organs and the CNS in mucopolysaccharidosis II in rodents and non-human primates.
Chen N, Ehmann DE, Crooker R, Derakhchan K, Fang X, Felice B, Galbreath EJ, Glaus C, Gu H, Huang Y, Li C, Li X, Liu N, Palmieri K, Simic D, Sypek J, Thompson S, Winkelmann CT, Choi VW. Chen N, et al. Among authors: galbreath ej. Mol Ther Methods Clin Dev. 2023 Mar 28;29:286-302. doi: 10.1016/j.omtm.2023.03.014. eCollection 2023 Jun 8. Mol Ther Methods Clin Dev. 2023. PMID: 37359415 Free PMC article.
Scientific and Regulatory Policy Committee Best Practices: Recommended ("Best") Practices for Informed (Non-blinded) Versus Masked (Blinded) Microscopic Evaluation in Animal Toxicity Studies.
Bolon B, Francke S, Caverly Rae JM, Polack E, Regan KS, McInnes EF, Young JK, Keane K, Perry R, Romeike A, Colman K, Jensen K, Nakano-Ito K, Galbreath EJ. Bolon B, et al. Among authors: galbreath ej. Toxicol Pathol. 2022 Dec;50(8):930-941. doi: 10.1177/01926233221135563. Epub 2022 Nov 14. Toxicol Pathol. 2022. PMID: 36377245
Scientific and Regulatory Policy Committee Points to Consider: Nonclinical Research and Development of In Vivo Gene Therapy Products, Emphasizing Adeno-Associated Virus Vectors.
Hutt JA, Assaf BT, Bolon B, Cavagnaro J, Galbreath E, Grubor B, Kattenhorn LM, Romeike A, Whiteley LO. Hutt JA, et al. Among authors: galbreath e. Toxicol Pathol. 2022 Jan;50(1):118-146. doi: 10.1177/01926233211041962. Epub 2021 Oct 17. Toxicol Pathol. 2022. PMID: 34657529 Review.
Classic and evolving approaches to evaluating cross reactivity of mAb and mAb-like molecules - A survey of industry 2008-2019.
MacLachlan TK, Price S, Cavagnaro J, Andrews L, Blanset D, Cosenza ME, Dempster M, Galbreath E, Giusti AM, Heinz-Taheny KM, Fleurance R, Sutter E, Leach MW. MacLachlan TK, et al. Among authors: galbreath e. Regul Toxicol Pharmacol. 2021 Apr;121:104872. doi: 10.1016/j.yrtph.2021.104872. Epub 2021 Jan 22. Regul Toxicol Pharmacol. 2021. PMID: 33485926
52 results