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Rational design, synthesis and evaluation of first generation inhibitors of the Giardia lamblia fructose-1,6-biphosphate aldolase.
Li Z, Liu Z, Cho DW, Zou J, Gong M, Breece RM, Galkin A, Li L, Zhao H, Maestas GD, Tierney DL, Herzberg O, Dunaway-Mariano D, Mariano PS. Li Z, et al. Among authors: galkin a. J Inorg Biochem. 2011 Apr;105(4):509-17. doi: 10.1016/j.jinorgbio.2010.12.012. Epub 2010 Dec 30. J Inorg Biochem. 2011. PMID: 21333622 Free PMC article.
Inactivation of microbial arginine deiminases by L-canavanine.
Li L, Li Z, Chen D, Lu X, Feng X, Wright EC, Solberg NO, Dunaway-Mariano D, Mariano PS, Galkin A, Kulakova L, Herzberg O, Green-Church KB, Zhang L. Li L, et al. Among authors: galkin a. J Am Chem Soc. 2008 Feb 13;130(6):1918-31. doi: 10.1021/ja0760877. Epub 2008 Jan 19. J Am Chem Soc. 2008. PMID: 18205354
Arginine deiminase uses an active-site cysteine in nucleophilic catalysis of L-arginine hydrolysis.
Lu X, Galkin A, Herzberg O, Dunaway-Mariano D. Lu X, et al. Among authors: galkin a. J Am Chem Soc. 2004 May 5;126(17):5374-5. doi: 10.1021/ja049543p. J Am Chem Soc. 2004. PMID: 15113205
These results, along with the recently reported enzyme X-ray structure (Galkin, A.; Kulakova, L.; Sarikaya, E.; Lim, K.; Howard, A.; Herzberg, O. J. Biol. Chem. 2004, 279, 14001-14008, evidence a reaction pathway in which l-arginine deimination proceed …
These results, along with the recently reported enzyme X-ray structure (Galkin, A.; Kulakova, L.; Sarikaya, E.; Lim, K.; Howar …
281 results