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Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?
Leclerc S, Garnier M, Hoessel R, Marko D, Bibb JA, Snyder GL, Greengard P, Biernat J, Wu YZ, Mandelkow EM, Eisenbrand G, Meijer L. Leclerc S, et al. Among authors: garnier m. J Biol Chem. 2001 Jan 5;276(1):251-60. doi: 10.1074/jbc.M002466200. J Biol Chem. 2001. PMID: 11013232 Free article.
Cinnamaldehydes inhibit cyclin dependent kinase 4/cyclin D1.
Jeong HW, Kim MR, Son KH, Han MY, Ha JH, Garnier M, Meijer L, Kwon BM. Jeong HW, et al. Among authors: garnier m. Bioorg Med Chem Lett. 2000 Aug 21;10(16):1819-22. doi: 10.1016/s0960-894x(00)00357-7. Bioorg Med Chem Lett. 2000. PMID: 10969976
424 results