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A Membrane-Bound Diacylglycerol Species Induces PKCϵ-Mediated Hepatic Insulin Resistance.
Lyu K, Zhang Y, Zhang D, Kahn M, Ter Horst KW, Rodrigues MRS, Gaspar RC, Hirabara SM, Luukkonen PK, Lee S, Bhanot S, Rinehart J, Blume N, Rasch MG, Serlie MJ, Bogan JS, Cline GW, Samuel VT, Shulman GI. Lyu K, et al. Among authors: gaspar rc. Cell Metab. 2020 Oct 6;32(4):654-664.e5. doi: 10.1016/j.cmet.2020.08.001. Epub 2020 Sep 2. Cell Metab. 2020. PMID: 32882164 Free PMC article.
Metformin, phenformin, and galegine inhibit complex IV activity and reduce glycerol-derived gluconeogenesis.
LaMoia TE, Butrico GM, Kalpage HA, Goedeke L, Hubbard BT, Vatner DF, Gaspar RC, Zhang XM, Cline GW, Nakahara K, Woo S, Shimada A, Hüttemann M, Shulman GI. LaMoia TE, et al. Among authors: gaspar rc. Proc Natl Acad Sci U S A. 2022 Mar 8;119(10):e2122287119. doi: 10.1073/pnas.2122287119. Epub 2022 Mar 1. Proc Natl Acad Sci U S A. 2022. PMID: 35238637 Free PMC article.
Distinct subcellular localisation of intramyocellular lipids and reduced PKCε/PKCθ activity preserve muscle insulin sensitivity in exercise-trained mice.
Gaspar RC, Lyu K, Hubbard BT, Leitner BP, Luukkonen PK, Hirabara SM, Sakuma I, Nasiri A, Zhang D, Kahn M, Cline GW, Pauli JR, Perry RJ, Petersen KF, Shulman GI. Gaspar RC, et al. Diabetologia. 2023 Mar;66(3):567-578. doi: 10.1007/s00125-022-05838-8. Epub 2022 Dec 1. Diabetologia. 2023. PMID: 36456864
Short-term Resistance Training Increases APPL1 Content in the Liver and the Insulin Sensitivity of Mice Fed a Long-term High-fat Diet.
Minuzzi LG, Kuga GK, Breda L, Gaspar RC, Muñoz VR, Pereira RM, Botezelli JD, da Silva ASR, Cintra DE, de Moura LP, Ropelle ER, Pauli JR. Minuzzi LG, et al. Among authors: gaspar rc. Exp Clin Endocrinol Diabetes. 2020 Jan;128(1):30-37. doi: 10.1055/a-0885-9872. Epub 2019 Apr 16. Exp Clin Endocrinol Diabetes. 2020. PMID: 30991419
Time-restricted feeding combined with aerobic exercise training can prevent weight gain and improve metabolic disorders in mice fed a high-fat diet.
Vieira RFL, Muñoz VR, Junqueira RL, de Oliveira F, Gaspar RC, Nakandakari SCBR, Costa SO, Torsoni MA, da Silva ASR, Cintra DE, de Moura LP, Ropelle ER, Zaghloul I, Mekary RA, Pauli JR. Vieira RFL, et al. Among authors: gaspar rc. J Physiol. 2022 Feb;600(4):797-813. doi: 10.1113/JP280820. Epub 2021 Jan 26. J Physiol. 2022. PMID: 33450053 Free article.
60 results