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Patients with oral squamous cell carcinoma are characterized by increased frequency of suppressive regulatory T cells in the blood and tumor microenvironment.
Gasparoto TH, de Souza Malaspina TS, Benevides L, de Melo EJ Jr, Costa MR, Damante JH, Ikoma MR, Garlet GP, Cavassani KA, da Silva JS, Campanelli AP. Gasparoto TH, et al. Cancer Immunol Immunother. 2010 Jun;59(6):819-28. doi: 10.1007/s00262-009-0803-7. Epub 2009 Dec 12. Cancer Immunol Immunother. 2010. PMID: 20012605 Free PMC article.
Enhanced programmed death 1 (PD-1) and PD-1 ligand (PD-L1) expression in patients with actinic cheilitis and oral squamous cell carcinoma.
Malaspina TS, Gasparoto TH, Costa MR, de Melo EF Jr, Ikoma MR, Damante JH, Cavassani KA, Garlet GP, da Silva JS, Campanelli AP. Malaspina TS, et al. Among authors: gasparoto th. Cancer Immunol Immunother. 2011 Jul;60(7):965-74. doi: 10.1007/s00262-011-1007-5. Epub 2011 Mar 27. Cancer Immunol Immunother. 2011. PMID: 21442435 Free PMC article.
PD-1 blockage delays murine squamous cell carcinoma development.
Belai EB, de Oliveira CE, Gasparoto TH, Ramos RN, Torres SA, Garlet GP, Cavassani KA, Silva JS, Campanelli AP. Belai EB, et al. Among authors: gasparoto th. Carcinogenesis. 2014 Feb;35(2):424-31. doi: 10.1093/carcin/bgt305. Epub 2013 Sep 12. Carcinogenesis. 2014. PMID: 24031027
Regulatory T cells in the actinic cheilitis.
Gasparoto TH, de Souza Malaspina TS, Damante JH, de Mello EF Jr, Ikoma MR, Garlet GP, Costa MR, Cavassani KA, da Silva JS, Campanelli AP. Gasparoto TH, et al. J Oral Pathol Med. 2014 Nov;43(10):754-60. doi: 10.1111/jop.12207. Epub 2014 Jul 24. J Oral Pathol Med. 2014. PMID: 25060152 Free article.
Inflammatory events during murine squamous cell carcinoma development.
Gasparoto TH, de Oliveira CE, de Freitas LT, Pinheiro CR, Ramos RN, da Silva AL, Garlet GP, da Silva JS, Campanelli AP. Gasparoto TH, et al. J Inflamm (Lond). 2012 Nov 23;9(1):46. doi: 10.1186/1476-9255-9-46. J Inflamm (Lond). 2012. PMID: 23176085 Free PMC article.
Immune Checkpoints in Leprosy: Immunotherapy As a Feasible Approach to Control Disease Progression.
Lima HR, Gasparoto TH, de Souza Malaspina TS, Marques VR, Vicente MJ, Marcos EC, Souza FC, Nogueira MRS, Barreto JA, Garlet GP, da Silva JS, Brito-de-Souza VN, Campanelli AP. Lima HR, et al. Among authors: gasparoto th. Front Immunol. 2017 Dec 11;8:1724. doi: 10.3389/fimmu.2017.01724. eCollection 2017. Front Immunol. 2017. PMID: 29312289 Free PMC article.
ST2/IL-33 signaling promotes malignant development of experimental squamous cell carcinoma by decreasing NK cells cytotoxicity and modulating the intratumoral cell infiltrate.
Amôr NG, de Oliveira CE, Gasparoto TH, Vilas Boas VG, Perri G, Kaneno R, Lara VS, Garlet GP, da Silva JS, Martins GA, Hogaboam C, Cavassani KA, Campanelli AP. Amôr NG, et al. Among authors: gasparoto th. Oncotarget. 2018 Jul 20;9(56):30894-30904. doi: 10.18632/oncotarget.25768. eCollection 2018 Jul 20. Oncotarget. 2018. PMID: 30112116 Free PMC article.
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