Gavaghan DJ - Search Results

1

Evaluation of an in silico cardiac safety assay: using ion channel screening data to predict QT interval changes in the rabbit ventricular wedge.

Beattie KA, Luscombe C, Williams G, Munoz-Muriedas J, Gavaghan DJ, Cui Y, Mirams GR. Beattie KA, et al. Among authors: gavaghan dj. J Pharmacol Toxicol Methods. 2013 Jul-Aug;68(1):88-96. doi: 10.1016/j.vascn.2013.04.004. Epub 2013 Apr 25. J Pharmacol Toxicol Methods. 2013. PMID: 23624022 Free PMC article.

2

A hybrid approach to multi-scale modelling of cancer.

Osborne JM, Walter A, Kershaw SK, Mirams GR, Fletcher AG, Pathmanathan P, Gavaghan D, Jensen OE, Maini PK, Byrne HM. Osborne JM, et al. Philos Trans A Math Phys Eng Sci. 2010 Nov 13;368(1930):5013-28. doi: 10.1098/rsta.2010.0173. Philos Trans A Math Phys Eng Sci. 2010. PMID: 20921009

3

Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk.

Mirams GR, Cui Y, Sher A, Fink M, Cooper J, Heath BM, McMahon NC, Gavaghan DJ, Noble D. Mirams GR, et al. Among authors: gavaghan dj. Cardiovasc Res. 2011 Jul 1;91(1):53-61. doi: 10.1093/cvr/cvr044. Epub 2011 Feb 7. Cardiovasc Res. 2011. PMID: 21300721 Free PMC article.

4

Chaste: an open source C++ library for computational physiology and biology.

Mirams GR, Arthurs CJ, Bernabeu MO, Bordas R, Cooper J, Corrias A, Davit Y, Dunn SJ, Fletcher AG, Harvey DG, Marsh ME, Osborne JM, Pathmanathan P, Pitt-Francis J, Southern J, Zemzemi N, Gavaghan DJ. Mirams GR, et al. Among authors: gavaghan dj. PLoS Comput Biol. 2013;9(3):e1002970. doi: 10.1371/journal.pcbi.1002970. Epub 2013 Mar 14. PLoS Comput Biol. 2013. PMID: 23516352 Free PMC article.

5

Variability in high-throughput ion-channel screening data and consequences for cardiac safety assessment.

Elkins RC, Davies MR, Brough SJ, Gavaghan DJ, Cui Y, Abi-Gerges N, Mirams GR. Elkins RC, et al. Among authors: gavaghan dj. J Pharmacol Toxicol Methods. 2013 Jul-Aug;68(1):112-22. doi: 10.1016/j.vascn.2013.04.007. Epub 2013 May 5. J Pharmacol Toxicol Methods. 2013. PMID: 23651875 Free PMC article.

6

Ten simple rules for effective computational research.

Osborne JM, Bernabeu MO, Bruna M, Calderhead B, Cooper J, Dalchau N, Dunn SJ, Fletcher AG, Freeman R, Groen D, Knapp B, McInerny GJ, Mirams GR, Pitt-Francis J, Sengupta B, Wright DW, Yates CA, Gavaghan DJ, Emmott S, Deane C. Osborne JM, et al. Among authors: gavaghan dj. PLoS Comput Biol. 2014 Mar 27;10(3):e1003506. doi: 10.1371/journal.pcbi.1003506. eCollection 2014 Mar. PLoS Comput Biol. 2014. PMID: 24675742 Free PMC article. No abstract available.

7

Prediction of Thorough QT study results using action potential simulations based on ion channel screens.

Mirams GR, Davies MR, Brough SJ, Bridgland-Taylor MH, Cui Y, Gavaghan DJ, Abi-Gerges N. Mirams GR, et al. Among authors: gavaghan dj. J Pharmacol Toxicol Methods. 2014 Nov-Dec;70(3):246-54. doi: 10.1016/j.vascn.2014.07.002. Epub 2014 Jul 31. J Pharmacol Toxicol Methods. 2014. PMID: 25087753 Free PMC article.

8

Cardiac tissue slices: preparation, handling, and successful optical mapping.

Wang K, Lee P, Mirams GR, Sarathchandra P, Borg TK, Gavaghan DJ, Kohl P, Bollensdorff C. Wang K, et al. Among authors: gavaghan dj. Am J Physiol Heart Circ Physiol. 2015 May 1;308(9):H1112-25. doi: 10.1152/ajpheart.00556.2014. Epub 2015 Jan 16. Am J Physiol Heart Circ Physiol. 2015. PMID: 25595366 Free PMC article.

9

Uncertainty and variability in models of the cardiac action potential: Can we build trustworthy models?

Johnstone RH, Chang ETY, Bardenet R, de Boer TP, Gavaghan DJ, Pathmanathan P, Clayton RH, Mirams GR. Johnstone RH, et al. Among authors: gavaghan dj. J Mol Cell Cardiol. 2016 Jul;96:49-62. doi: 10.1016/j.yjmcc.2015.11.018. Epub 2015 Dec 2. J Mol Cell Cardiol. 2016. PMID: 26611884 Free PMC article.

10

Hierarchical Bayesian inference for ion channel screening dose-response data.

Johnstone RH, Bardenet R, Gavaghan DJ, Mirams GR. Johnstone RH, et al. Among authors: gavaghan dj. Wellcome Open Res. 2016 Nov 15;1:6. doi: 10.12688/wellcomeopenres.9945.2. eCollection 2016. Wellcome Open Res. 2016. PMID: 27918599 Free PMC article.

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