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NK cells developing in vitro from fetal mouse progenitors express at least one member of the Ly49 family that is acquired in a time-dependent and stochastic manner independently of CD94 and NKG2.
Fraser KP, Gays F, Robinson JH, van Beneden K, Leclercq G, Vance RE, Raulet DH, Brooks CG. Fraser KP, et al. Among authors: gays f. Eur J Immunol. 2002 Mar;32(3):868-78. doi: 10.1002/1521-4141(200203)32:3<868::AID-IMMU868>3.0.CO;2-A. Eur J Immunol. 2002. PMID: 11870631 Free article.
Stochastic acquisition of Qa1 receptors during the development of fetal NK cells in vitro accounts in part but not in whole for the ability of these cells to distinguish between class I-sufficient and class I-deficient targets.
Toomey JA, Salcedo M, Cotterill LA, Millrain MM, Chrzanowska-Lightowlers Z, Lawry J, Fraser K, Gays F, Robinson JH, Shrestha S, Dyson PJ, Brooks CG. Toomey JA, et al. Among authors: gays f. J Immunol. 1999 Sep 15;163(6):3176-84. J Immunol. 1999. PMID: 10477585
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