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The lysosomotrope GPN mobilises Ca2+ from acidic organelles.
Yuan Y, Kilpatrick BS, Gerndt S, Bracher F, Grimm C, Schapira AH, Patel S. Yuan Y, et al. Among authors: gerndt s. J Cell Sci. 2021 Mar 11;134(6):jcs256578. doi: 10.1242/jcs.256578. J Cell Sci. 2021. PMID: 33602742 Free PMC article.
Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function.
Gerndt S, Chen CC, Chao YK, Yuan Y, Burgstaller S, Scotto Rosato A, Krogsaeter E, Urban N, Jacob K, Nguyen ONP, Miller MT, Keller M, Vollmar AM, Gudermann T, Zierler S, Schredelseker J, Schaefer M, Biel M, Malli R, Wahl-Schott C, Bracher F, Patel S, Grimm C. Gerndt S, et al. Elife. 2020 Mar 16;9:e54712. doi: 10.7554/eLife.54712. Elife. 2020. PMID: 32167471 Free PMC article.
Discovery of lipophilic two-pore channel agonists.
Gerndt S, Krogsaeter E, Patel S, Bracher F, Grimm C. Gerndt S, et al. FEBS J. 2020 Dec;287(24):5284-5293. doi: 10.1111/febs.15432. Epub 2020 Jun 14. FEBS J. 2020. PMID: 32478984 Free article. Review.
Gene editing and synthetically accessible inhibitors reveal role for TPC2 in HCC cell proliferation and tumor growth.
Müller M, Gerndt S, Chao YK, Zisis T, Nguyen ONP, Gerwien A, Urban N, Müller C, Gegenfurtner FA, Geisslinger F, Ortler C, Chen CC, Zahler S, Biel M, Schaefer M, Grimm C, Bracher F, Vollmar AM, Bartel K. Müller M, et al. Among authors: gerndt s. Cell Chem Biol. 2021 Aug 19;28(8):1119-1131.e27. doi: 10.1016/j.chembiol.2021.01.023. Epub 2021 Feb 23. Cell Chem Biol. 2021. PMID: 33626324 Free article.
Tracheal Chondrosarcoma-A Novel Presentation of Lynch Syndrome.
Bhat AM, Gerndt S, Sandhu A, Helfand AM, Jiwani R, Low GMI. Bhat AM, et al. Among authors: gerndt s. JAMA Otolaryngol Head Neck Surg. 2024 Feb 1;150(2):183-184. doi: 10.1001/jamaoto.2023.3908. JAMA Otolaryngol Head Neck Surg. 2024. PMID: 38095912
Sensitive MRD Detection from Lymphatic Fluid after Surgery in HPV-Associated Oropharyngeal Cancer.
Earland N, Semenkovich NP, Ramirez RJ, Gerndt SP, Harris PK, Gu Z, Hearn AI, Inkman M, Szymanski JJ, Whitfield D, Wahle BM, Xu Z, Chen K, Alahi I, Ni G, Chen A, Winckler W, Zhang J, Chaudhuri AA, Zevallos JP. Earland N, et al. Among authors: gerndt sp. Clin Cancer Res. 2024 Apr 1;30(7):1409-1421. doi: 10.1158/1078-0432.CCR-23-1789. Clin Cancer Res. 2024. PMID: 37939112 Free PMC article.
Targeted Proteomic Quantitation of NRF2 Signaling and Predictive Biomarkers in HNSCC.
Wamsley NT, Wilkerson EM, Guan L, LaPak KM, Schrank TP, Holmes BJ, Sprung RW, Gilmore PE, Gerndt SP, Jackson RS, Paniello RC, Pipkorn P, Puram SV, Rich JT, Townsend RR, Zevallos JP, Zolkind P, Le QT, Goldfarb D, Major MB. Wamsley NT, et al. Among authors: gerndt sp. Mol Cell Proteomics. 2023 Nov;22(11):100647. doi: 10.1016/j.mcpro.2023.100647. Epub 2023 Sep 15. Mol Cell Proteomics. 2023. PMID: 37716475 Free PMC article.
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