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Oleanolic acid induces a dual agonist action on PPARγ/α and GLUT4 translocation: A pentacyclic triterpene for dyslipidemia and type 2 diabetes.
Loza-Rodríguez H, Estrada-Soto S, Alarcón-Aguilar FJ, Huang F, Aquino-Jarquín G, Fortis-Barrera Á, Giacoman-Martínez A, Almanza-Pérez JC. Loza-Rodríguez H, et al. Among authors: giacoman martinez a. Eur J Pharmacol. 2020 Sep 15;883:173252. doi: 10.1016/j.ejphar.2020.173252. Epub 2020 Jun 10. Eur J Pharmacol. 2020. PMID: 32534078
Discovery of new dual PPARγ-GPR40 agonists with robust antidiabetic activity: Design, synthesis and in combo drug evaluation.
Hidalgo-Figueroa S, Navarrete-Vázquez G, Estrada-Soto S, Giles-Rivas D, Alarcón-Aguilar FJ, León-Rivera I, Giacoman-Martínez A, Miranda Pérez E, Almanza-Pérez JC. Hidalgo-Figueroa S, et al. Biomed Pharmacother. 2017 Jun;90:53-61. doi: 10.1016/j.biopha.2017.03.033. Epub 2017 Mar 22. Biomed Pharmacother. 2017. PMID: 28342366
Design, Synthesis and in Combo Antidiabetic Bioevaluation of Multitarget Phenylpropanoic Acids.
Colín-Lozano B, Estrada-Soto S, Chávez-Silva F, Gutiérrez-Hernández A, Cerón-Romero L, Giacoman-Martínez A, Almanza-Pérez JC, Hernández-Núñez E, Wang Z, Xie X, Cappiello M, Balestri F, Mura U, Navarrete-Vazquez G. Colín-Lozano B, et al. Molecules. 2018 Feb 6;23(2):340. doi: 10.3390/molecules23020340. Molecules. 2018. PMID: 29415496 Free PMC article.
Design, synthesis, in vitro, in vivo and in silico pharmacological characterization of antidiabetic N-Boc-l-tyrosine-based compounds.
Herrera-Rueda MÁ, Tlahuext H, Paoli P, Giacoman-Martínez A, Almanza-Pérez JC, Pérez-Sánchez H, Gutiérrez-Hernández A, Chávez-Silva F, Dominguez-Mendoza EA, Estrada-Soto S, Navarrete-Vazquez G. Herrera-Rueda MÁ, et al. Biomed Pharmacother. 2018 Dec;108:670-678. doi: 10.1016/j.biopha.2018.09.074. Epub 2018 Sep 21. Biomed Pharmacother. 2018. PMID: 30245467 Free article.
Glycine is a competitive antagonist of the TNF receptor mediating the expression of inflammatory cytokines in 3T3-L1 adipocytes.
Romero-Nava R, Alarcón-Aguilar FJ, Giacoman-Martínez A, Blancas-Flores G, Aguayo-Cerón KA, Ballinas-Verdugo MA, Sánchez-Muñoz F, Huang F, Villafaña-Rauda S, Almanza-Pérez JC. Romero-Nava R, et al. Among authors: giacoman martinez a. Inflamm Res. 2021 May;70(5):605-618. doi: 10.1007/s00011-021-01462-1. Epub 2021 Apr 20. Inflamm Res. 2021. PMID: 33877377
Synthesis, molecular docking, dynamic simulation and pharmacological characterization of potent multifunctional agent (dual GPR40-PPARγ agonist) for the treatment of experimental type 2 diabetes.
Hidalgo-Figueroa S, Rodríguez-Luévano A, Almanza-Pérez JC, Giacoman-Martínez A, Ortiz-Andrade R, León-Rivera I, Navarrete-Vázquez G. Hidalgo-Figueroa S, et al. Among authors: giacoman martinez a. Eur J Pharmacol. 2021 Sep 15;907:174244. doi: 10.1016/j.ejphar.2021.174244. Epub 2021 Jun 8. Eur J Pharmacol. 2021. PMID: 34116041
Associations of TNFA, IL17A, and RORC mRNA expression levels in peripheral blood leukocytes with obesity-related asthma in adolescents.
Leija-Martínez JJ, Del-Río-Navarro BE, Sanchéz-Muñoz F, Muñoz-Hernández O, Hong E, Giacoman-Martínez A, Romero-Nava R, Patricio-Román KL, Hall-Mondragon MS, Espinosa-Velazquez D, Villafaña S, Huang F. Leija-Martínez JJ, et al. Among authors: giacoman martinez a. Clin Immunol. 2021 Aug;229:108715. doi: 10.1016/j.clim.2021.108715. Epub 2021 Mar 23. Clin Immunol. 2021. PMID: 33771687
High fructose exposure modifies the amount of adipocyte-secreted microRNAs into extracellular vesicles in supernatants and plasma.
Hernández-Díazcouder A, González-Ramírez J, Giacoman-Martínez A, Cardoso-Saldaña G, Martínez-Martínez E, Osorio-Alonso H, Márquez-Velasco R, Sánchez-Gloria JL, Juárez-Vicuña Y, Gonzaga G, Sánchez-Lozada LG, Almanza-Pérez JC, Sánchez-Muñoz F. Hernández-Díazcouder A, et al. Among authors: giacoman martinez a. PeerJ. 2021 May 19;9:e11305. doi: 10.7717/peerj.11305. eCollection 2021. PeerJ. 2021. PMID: 34055478 Free PMC article.
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