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Dual Inhibition of PDK1 and Aurora Kinase A: An Effective Strategy to Induce Differentiation and Apoptosis of Human Glioblastoma Multiforme Stem Cells.
Daniele S, Sestito S, Pietrobono D, Giacomelli C, Chiellini G, Di Maio D, Marinelli L, Novellino E, Martini C, Rapposelli S. Daniele S, et al. Among authors: giacomelli c. ACS Chem Neurosci. 2017 Jan 18;8(1):100-114. doi: 10.1021/acschemneuro.6b00251. Epub 2016 Nov 10. ACS Chem Neurosci. 2017. PMID: 27797168
A new D₂ dopamine receptor agonist allosterically modulates A(2A) adenosine receptor signalling by interacting with the A(2A)/D₂ receptor heteromer.
Trincavelli ML, Daniele S, Orlandini E, Navarro G, Casadó V, Giacomelli C, Nencetti S, Nuti E, Macchia M, Huebner H, Gmeiner P, Rossello A, Lluís C, Martini C. Trincavelli ML, et al. Among authors: giacomelli c. Cell Signal. 2012 Apr;24(4):951-60. doi: 10.1016/j.cellsig.2011.12.018. Epub 2011 Dec 30. Cell Signal. 2012. PMID: 22230688
Modulation of A2B adenosine receptor by 1-Benzyl-3-ketoindole derivatives.
Taliani S, Trincavelli ML, Cosimelli B, Laneri S, Severi E, Barresi E, Pugliesi I, Daniele S, Giacomelli C, Greco G, Novellino E, Martini C, Da Settimo F. Taliani S, et al. Among authors: giacomelli c. Eur J Med Chem. 2013 Nov;69:331-7. doi: 10.1016/j.ejmech.2013.09.001. Epub 2013 Sep 8. Eur J Med Chem. 2013. PMID: 24077183
Allosteric modulators of human A2B adenosine receptor.
Trincavelli ML, Giacomelli C, Daniele S, Taliani S, Cosimelli B, Laneri S, Severi E, Barresi E, Pugliesi I, Greco G, Novellino E, Da Settimo F, Martini C. Trincavelli ML, et al. Among authors: giacomelli c. Biochim Biophys Acta. 2014 Mar;1840(3):1194-203. doi: 10.1016/j.bbagen.2013.12.021. Epub 2013 Dec 19. Biochim Biophys Acta. 2014. PMID: 24361612
Apoptosis therapy in cancer: the first single-molecule co-activating p53 and the translocator protein in glioblastoma.
Daniele S, Taliani S, Da Pozzo E, Giacomelli C, Costa B, Trincavelli ML, Rossi L, La Pietra V, Barresi E, Carotenuto A, Limatola A, Lamberti A, Marinelli L, Novellino E, Da Settimo F, Martini C. Daniele S, et al. Among authors: giacomelli c. Sci Rep. 2014 Apr 23;4:4749. doi: 10.1038/srep04749. Sci Rep. 2014. PMID: 24756113 Free PMC article.
Further studies on pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as potent and selective human A1 adenosine receptor antagonists.
Giovannoni MP, Ciciani G, Cilibrizzi A, Crocetti L, Daniele S, Di Cesare Mannelli L, Ghelardini C, Giacomelli C, Guerrini G, Martini C, Trincavelli ML, Vergelli C. Giovannoni MP, et al. Among authors: giacomelli c. Eur J Med Chem. 2015 Jan 7;89:32-41. doi: 10.1016/j.ejmech.2014.10.020. Epub 2014 Oct 12. Eur J Med Chem. 2015. PMID: 25462223
181 results