Gibbs JP - Search Results

1

Reaction phenotyping in drug discovery: moving forward with confidence?

Williams JA, Hurst SI, Bauman J, Jones BC, Hyland R, Gibbs JP, Obach RS, Ball SE. Williams JA, et al. Among authors: gibbs jp. Curr Drug Metab. 2003 Dec;4(6):527-34. doi: 10.2174/1389200033489235. Curr Drug Metab. 2003. PMID: 14683480 Review.

2

Minimizing polymorphic metabolism in drug discovery: evaluation of the utility of in vitro methods for predicting pharmacokinetic consequences associated with CYP2D6 metabolism.

Gibbs JP, Hyland R, Youdim K. Gibbs JP, et al. Drug Metab Dispos. 2006 Sep;34(9):1516-22. doi: 10.1124/dmd.105.008714. Epub 2006 Jun 8. Drug Metab Dispos. 2006. PMID: 16763018

3

The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A/1B knockout mouse model.

Doran A, Obach RS, Smith BJ, Hosea NA, Becker S, Callegari E, Chen C, Chen X, Choo E, Cianfrogna J, Cox LM, Gibbs JP, Gibbs MA, Hatch H, Hop CE, Kasman IN, Laperle J, Liu J, Liu X, Logman M, Maclin D, Nedza FM, Nelson F, Olson E, Rahematpura S, Raunig D, Rogers S, Schmidt K, Spracklin DK, Szewc M, Troutman M, Tseng E, Tu M, Van Deusen JW, Venkatakrishnan K, Walens G, Wang EQ, Wong D, Yasgar AS, Zhang C. Doran A, et al. Among authors: gibbs jp, gibbs ma. Drug Metab Dispos. 2005 Jan;33(1):165-74. doi: 10.1124/dmd.104.001230. Epub 2004 Oct 22. Drug Metab Dispos. 2005. PMID: 15502009

4

Evaluation of cerebrospinal fluid concentration and plasma free concentration as a surrogate measurement for brain free concentration.

Liu X, Smith BJ, Chen C, Callegari E, Becker SL, Chen X, Cianfrogna J, Doran AC, Doran SD, Gibbs JP, Hosea N, Liu J, Nelson FR, Szewc MA, Van Deusen J. Liu X, et al. Among authors: gibbs jp. Drug Metab Dispos. 2006 Sep;34(9):1443-7. doi: 10.1124/dmd.105.008201. Epub 2006 Jun 7. Drug Metab Dispos. 2006. PMID: 16760229

5

Application of in vivo animal models to characterize the pharmacokinetic and pharmacodynamic properties of drug candidates in discovery settings.

Amore BM, Gibbs JP, Emery MG. Amore BM, et al. Among authors: gibbs jp. Comb Chem High Throughput Screen. 2010 Feb;13(2):207-18. doi: 10.2174/138620710790596808. Comb Chem High Throughput Screen. 2010. PMID: 20053166 Review.

6

Use of a physiologically based pharmacokinetic model to study the time to reach brain equilibrium: an experimental analysis of the role of blood-brain barrier permeability, plasma protein binding, and brain tissue binding.

Liu X, Smith BJ, Chen C, Callegari E, Becker SL, Chen X, Cianfrogna J, Doran AC, Doran SD, Gibbs JP, Hosea N, Liu J, Nelson FR, Szewc MA, Van Deusen J. Liu X, et al. Among authors: gibbs jp. J Pharmacol Exp Ther. 2005 Jun;313(3):1254-62. doi: 10.1124/jpet.104.079319. Epub 2005 Mar 2. J Pharmacol Exp Ther. 2005. PMID: 15743928

7

Quantitative prediction of human pharmacokinetics for monoclonal antibodies: retrospective analysis of monkey as a single species for first-in-human prediction.

Dong JQ, Salinger DH, Endres CJ, Gibbs JP, Hsu CP, Stouch BJ, Hurh E, Gibbs MA. Dong JQ, et al. Among authors: gibbs jp, gibbs ma. Clin Pharmacokinet. 2011 Feb;50(2):131-42. doi: 10.2165/11537430-000000000-00000. Clin Pharmacokinet. 2011. PMID: 21241072

8

Dose adjustment of venetoclax when co-administered with posaconazole: clinical drug-drug interaction predictions using a PBPK approach.

Bhatnagar S, Mukherjee D, Salem AH, Miles D, Menon RM, Gibbs JP. Bhatnagar S, et al. Among authors: gibbs jp. Cancer Chemother Pharmacol. 2021 Apr;87(4):465-474. doi: 10.1007/s00280-020-04179-w. Epub 2021 Jan 4. Cancer Chemother Pharmacol. 2021. PMID: 33398386

9

Population genomic structure of a widespread, urban-dwelling mammal: The eastern grey squirrel (Sciurus carolinensis).

Fusco NA, Cosentino BJ, Gibbs JP, Allen ML, Blumenfeld AJ, Boettner GH, Carlen EJ, Collins M, Dennison C, DiGiacopo D, Drapeau Picard AP, Edmonson J, Fisher-Reid MC, Fyffe R, Gallo T, Grant A, Harbold W, Heard SB, Lafferty DJR, Lehtinen RM, Marino S, McDonald JE, Mortelliti A, Murray M, Newman A, Oswald KN, Ott-Conn C, Richardson JL, Rimbach R, Salaman P, Steele M, Stothart MR, Urban MC, Vandegrift K, Vanek JP, Vanderluit SN, Vezina L, Caccone A. Fusco NA, et al. Among authors: gibbs jp. Mol Ecol. 2024 Feb;33(3):e17230. doi: 10.1111/mec.17230. Epub 2023 Dec 11. Mol Ecol. 2024. PMID: 38078558

10

Rural selection drives the evolution of an urban-rural cline in coat color in gray squirrels.

Cosentino BJ, Vanek JP, Gibbs JP. Cosentino BJ, et al. Among authors: gibbs jp. Ecol Evol. 2023 Oct 10;13(10):e10544. doi: 10.1002/ece3.10544. eCollection 2023 Oct. Ecol Evol. 2023. PMID: 37829180 Free PMC article.

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