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Therapeutic efficacy of an Ad26/MVA vaccine with SIV gp140 protein and vesatolimod in ART-suppressed rhesus macaques.
Ventura JD, Nkolola JP, Chandrashekar A, Borducchi EN, Liu J, Mercado NB, Hope DL, Giffin VM, McMahan K, Geleziunas R, Murry JP, Yang Y, Lewis MG, Pau MG, Wegmann F, Schuitemaker H, Fray EJ, Kumar MR, Siliciano JD, Siliciano RF, Robb ML, Michael NL, Barouch DH. Ventura JD, et al. Among authors: giffin vm. NPJ Vaccines. 2022 May 18;7(1):53. doi: 10.1038/s41541-022-00477-x. NPJ Vaccines. 2022. PMID: 35585080 Free PMC article.
Protective efficacy of Ad26.COV2.S against SARS-CoV-2 B.1.351 in macaques.
Yu J, Tostanoski LH, Mercado NB, McMahan K, Liu J, Jacob-Dolan C, Chandrashekar A, Atyeo C, Martinez DR, Anioke T, Bondzie EA, Chang A, Gardner S, Giffin VM, Hope DL, Nampanya F, Nkolola J, Patel S, Sanborn O, Sellers D, Wan H, Hayes T, Bauer K, Pessaint L, Valentin D, Flinchbaugh Z, Brown R, Cook A, Bueno-Wilkerson D, Teow E, Andersen H, Lewis MG, Martinot AJ, Baric RS, Alter G, Wegmann F, Zahn R, Schuitemaker H, Barouch DH. Yu J, et al. Among authors: giffin vm. Nature. 2021 Aug;596(7872):423-427. doi: 10.1038/s41586-021-03732-8. Epub 2021 Jun 23. Nature. 2021. PMID: 34161961 Free PMC article.
Prior infection with SARS-CoV-2 WA1/2020 partially protects rhesus macaques against reinfection with B.1.1.7 and B.1.351 variants.
Chandrashekar A, Liu J, Yu J, McMahan K, Tostanoski LH, Jacob-Dolan C, Mercado NB, Anioke T, Chang A, Gardner S, Giffin VM, Hope DL, Nampanya F, Patel S, Sanborn O, Sellers D, Wan H, Martinot AJ, Baczenas JJ, O'Connor SL, Pessaint L, Valentin D, Espina B, Wattay L, Ferrari MG, Brown R, Cook A, Bueno-Wilkerson D, Teow E, Andersen H, Lewis MG, Barouch DH. Chandrashekar A, et al. Among authors: giffin vm. Sci Transl Med. 2021 Nov 3;13(618):eabj2641. doi: 10.1126/scitranslmed.abj2641. Epub 2021 Nov 3. Sci Transl Med. 2021. PMID: 34546094 Free PMC article.
Immunity elicited by natural infection or Ad26.COV2.S vaccination protects hamsters against SARS-CoV-2 variants of concern.
Tostanoski LH, Yu J, Mercado NB, McMahan K, Jacob-Dolan C, Martinot AJ, Piedra-Mora C, Anioke T, Chang A, Giffin VM, Hope DL, Wan H, Bondzie EA, Mahrokhian SH, Wrijil LM, Bauer K, Pessaint L, Porto M, Piegols J, Faudree A, Spence B, Kar S, Amanat F, Krammer F, Andersen H, Lewis MG, Wegmann F, Zahn R, Schuitemaker H, Barouch DH. Tostanoski LH, et al. Among authors: giffin vm. Sci Transl Med. 2021 Nov 3;13(618):eabj3789. doi: 10.1126/scitranslmed.abj3789. Epub 2021 Nov 3. Sci Transl Med. 2021. PMID: 34705477 Free PMC article.
Optimization of non-coding regions for a non-modified mRNA COVID-19 vaccine.
Gebre MS, Rauch S, Roth N, Yu J, Chandrashekar A, Mercado NB, He X, Liu J, McMahan K, Martinot A, Martinez DR, Giffin V, Hope D, Patel S, Sellers D, Sanborn O, Barrett J, Liu X, Cole AC, Pessaint L, Valentin D, Flinchbaugh Z, Yalley-Ogunro J, Muench J, Brown R, Cook A, Teow E, Andersen H, Lewis MG, Boon ACM, Baric RS, Mueller SO, Petsch B, Barouch DH. Gebre MS, et al. Nature. 2022 Jan;601(7893):410-414. doi: 10.1038/s41586-021-04231-6. Epub 2021 Nov 18. Nature. 2022. PMID: 34794169 Free PMC article.
CD8 T cells contribute to vaccine protection against SARS-CoV-2 in macaques.
Liu J, Yu J, McMahan K, Jacob-Dolan C, He X, Giffin V, Wu C, Sciacca M, Powers O, Nampanya F, Miller J, Lifton M, Hope D, Hall K, Hachmann NP, Chung B, Anioke T, Li W, Muench J, Gamblin A, Boursiquot M, Cook A, Lewis MG, Andersen H, Barouch DH. Liu J, et al. Sci Immunol. 2022 Nov 18;7(77):eabq7647. doi: 10.1126/sciimmunol.abq7647. Epub 2022 Nov 11. Sci Immunol. 2022. PMID: 35943359 Free PMC article.
Protective Efficacy of Gastrointestinal SARS-CoV-2 Delivery against Intranasal and Intratracheal SARS-CoV-2 Challenge in Rhesus Macaques.
Yu J, Collins ND, Mercado NB, McMahan K, Chandrashekar A, Liu J, Anioke T, Chang A, Giffin VM, Hope DL, Sellers D, Nampanya F, Gardner S, Barrett J, Wan H, Velasco J, Teow E, Cook A, Van Ry A, Pessaint L, Andersen H, Lewis MG, Hofer C, Burke DS, Barkei EK, King HAD, Subra C, Bolton D, Modjarrad K, Michael NL, Barouch DH. Yu J, et al. Among authors: giffin vm. J Virol. 2022 Jan 26;96(2):e0159921. doi: 10.1128/JVI.01599-21. Epub 2021 Oct 27. J Virol. 2022. PMID: 34705557 Free PMC article.
Reduced SARS-CoV-2 disease outcomes in Syrian hamsters receiving immune sera: Quantitative image analysis in pathologic assessments.
Piedra-Mora C, Robinson SR, Tostanoski LH, Dayao DAE, Chandrashekar A, Bauer K, Wrijil L, Ducat S, Hayes T, Yu J, Bondzie EA, McMahan K, Sellers D, Giffin V, Hope D, Nampanya F, Mercado NB, Kar S, Andersen H, Tzipori S, Barouch DH, Martinot AJ. Piedra-Mora C, et al. Vet Pathol. 2022 Jul;59(4):648-660. doi: 10.1177/03009858221095794. Epub 2022 May 6. Vet Pathol. 2022. PMID: 35521761
SARS-CoV-2 receptor binding domain displayed on HBsAg virus-like particles elicits protective immunity in macaques.
Dalvie NC, Tostanoski LH, Rodriguez-Aponte SA, Kaur K, Bajoria S, Kumru OS, Martinot AJ, Chandrashekar A, McMahan K, Mercado NB, Yu J, Chang A, Giffin VM, Nampanya F, Patel S, Bowman L, Naranjo CA, Yun D, Flinchbaugh Z, Pessaint L, Brown R, Velasco J, Teow E, Cook A, Andersen H, Lewis MG, Camp DL, Silverman JM, Nagar GS, Rao HD, Lothe RR, Chandrasekharan R, Rajurkar MP, Shaligram US, Kleanthous H, Joshi SB, Volkin DB, Biswas S, Love JC, Barouch DH. Dalvie NC, et al. Among authors: giffin vm. Sci Adv. 2022 Mar 18;8(11):eabl6015. doi: 10.1126/sciadv.abl6015. Epub 2022 Mar 16. Sci Adv. 2022. PMID: 35294244 Free PMC article.
Reduced pathogenicity of the SARS-CoV-2 omicron variant in hamsters.
McMahan K, Giffin V, Tostanoski LH, Chung B, Siamatu M, Suthar MS, Halfmann P, Kawaoka Y, Piedra-Mora C, Jain N, Ducat S, Kar S, Andersen H, Lewis MG, Martinot AJ, Barouch DH. McMahan K, et al. Med. 2022 Apr 8;3(4):262-268.e4. doi: 10.1016/j.medj.2022.03.004. Epub 2022 Mar 17. Med. 2022. PMID: 35313451 Free PMC article.
11 results