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Tubuloids derived from human adult kidney and urine for personalized disease modeling.
Schutgens F, Rookmaaker MB, Margaritis T, Rios A, Ammerlaan C, Jansen J, Gijzen L, Vormann M, Vonk A, Viveen M, Yengej FY, Derakhshan S, de Winter-de Groot KM, Artegiani B, van Boxtel R, Cuppen E, Hendrickx APA, van den Heuvel-Eibrink MM, Heitzer E, Lanz H, Beekman J, Murk JL, Masereeuw R, Holstege F, Drost J, Verhaar MC, Clevers H. Schutgens F, et al. Among authors: gijzen l. Nat Biotechnol. 2019 Mar;37(3):303-313. doi: 10.1038/s41587-019-0048-8. Epub 2019 Mar 4. Nat Biotechnol. 2019. PMID: 30833775
Culture and analysis of kidney tubuloids and perfused tubuloid cells-on-a-chip.
Gijzen L, Yousef Yengej FA, Schutgens F, Vormann MK, Ammerlaan CME, Nicolas A, Kurek D, Vulto P, Rookmaaker MB, Lanz HL, Verhaar MC, Clevers H. Gijzen L, et al. Nat Protoc. 2021 Apr;16(4):2023-2050. doi: 10.1038/s41596-020-00479-w. Epub 2021 Mar 5. Nat Protoc. 2021. PMID: 33674788
Nephrotoxicity and Kidney Transport Assessment on 3D Perfused Proximal Tubules.
Vormann MK, Gijzen L, Hutter S, Boot L, Nicolas A, van den Heuvel A, Vriend J, Ng CP, Nieskens TTG, van Duinen V, de Wagenaar B, Masereeuw R, Suter-Dick L, Trietsch SJ, Wilmer M, Joore J, Vulto P, Lanz HL. Vormann MK, et al. Among authors: gijzen l. AAPS J. 2018 Aug 14;20(5):90. doi: 10.1208/s12248-018-0248-z. AAPS J. 2018. PMID: 30109442
A Novel In Vitro Membrane Permeability Methodology Using Three-dimensional Caco-2 Tubules in a Microphysiological System Which Better Mimics In Vivo Physiological Conditions.
Hagiwara Y, Kumagai H, Ouwerkerk N, Gijzen L, Annida R, Bokkers M, van Vught R, Yoshinari K, Katakawa Y, Motonaga K, Tajiri T. Hagiwara Y, et al. Among authors: gijzen l. J Pharm Sci. 2022 Jan;111(1):214-224. doi: 10.1016/j.xphs.2021.11.016. Epub 2021 Nov 25. J Pharm Sci. 2022. PMID: 34838780
Implementation of a Human Renal Proximal Tubule on a Chip for Nephrotoxicity and Drug Interaction Studies.
Vormann MK, Vriend J, Lanz HL, Gijzen L, van den Heuvel A, Hutter S, Joore J, Trietsch SJ, Stuut C, Nieskens TTG, Peters JGP, Ramp D, Caj M, Russel FGM, Jacobsen B, Roth A, Lu S, Polli JW, Naidoo AA, Vulto P, Masereeuw R, Wilmer MJ, Suter-Dick L. Vormann MK, et al. Among authors: gijzen l. J Pharm Sci. 2021 Apr;110(4):1601-1614. doi: 10.1016/j.xphs.2021.01.028. Epub 2021 Feb 3. J Pharm Sci. 2021. PMID: 33545187 Free article.
Modelling and Prevention of Acute Kidney Injury through Ischemia and Reperfusion in a Combined Human Renal Proximal Tubule/Blood Vessel-on-a-Chip.
Vormann MK, Tool LM, Ohbuchi M, Gijzen L, van Vught R, Hankemeier T, Kiyonaga F, Kawabe T, Goto T, Fujimori A, Vulto P, Lanz HL, Tetsuka K. Vormann MK, et al. Among authors: gijzen l. Kidney360. 2021 Nov 4;3(2):217-231. doi: 10.34067/KID.0003622021. eCollection 2022 Feb 24. Kidney360. 2021. PMID: 35373131 Free PMC article.