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A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states.
Dräger NM, Sattler SM, Huang CT, Teter OM, Leng K, Hashemi SH, Hong J, Aviles G, Clelland CD, Zhan L, Udeochu JC, Kodama L, Singleton AB, Nalls MA, Ichida J, Ward ME, Faghri F, Gan L, Kampmann M. Dräger NM, et al. Among authors: aviles g. Nat Neurosci. 2022 Sep;25(9):1149-1162. doi: 10.1038/s41593-022-01131-4. Epub 2022 Aug 11. Nat Neurosci. 2022. PMID: 35953545 Free PMC article.
DELE1 oligomerization promotes integrated stress response activation.
Yang J, Baron KR, Pride DE, Schneemann A, Guo X, Chen W, Song AS, Aviles G, Kampmann M, Wiseman RL, Lander GC. Yang J, et al. Among authors: aviles g. Nat Struct Mol Biol. 2023 Sep;30(9):1295-1302. doi: 10.1038/s41594-023-01061-0. Epub 2023 Aug 7. Nat Struct Mol Biol. 2023. PMID: 37550454 Free PMC article.