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Mechanically activated ion channel PIEZO1 is required for lymphatic valve formation.
Nonomura K, Lukacs V, Sweet DT, Goddard LM, Kanie A, Whitwam T, Ranade SS, Fujimori T, Kahn ML, Patapoutian A. Nonomura K, et al. Among authors: goddard lm. Proc Natl Acad Sci U S A. 2018 Dec 11;115(50):12817-12822. doi: 10.1073/pnas.1817070115. Epub 2018 Nov 27. Proc Natl Acad Sci U S A. 2018. PMID: 30482854 Free PMC article.
A BMPy Road for Venous Development.
Goddard LM, Kahn ML. Goddard LM, et al. Dev Cell. 2017 Sep 11;42(5):435-436. doi: 10.1016/j.devcel.2017.08.016. Dev Cell. 2017. PMID: 28898672 Free article.
Hemodynamic Forces Sculpt Developing Heart Valves through a KLF2-WNT9B Paracrine Signaling Axis.
Goddard LM, Duchemin AL, Ramalingan H, Wu B, Chen M, Bamezai S, Yang J, Li L, Morley MP, Wang T, Scherrer-Crosbie M, Frank DB, Engleka KA, Jameson SC, Morrisey EE, Carroll TJ, Zhou B, Vermot J, Kahn ML. Goddard LM, et al. Dev Cell. 2017 Nov 6;43(3):274-289.e5. doi: 10.1016/j.devcel.2017.09.023. Epub 2017 Oct 19. Dev Cell. 2017. PMID: 29056552 Free PMC article.
Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling.
Zhou Z, Tang AT, Wong WY, Bamezai S, Goddard LM, Shenkar R, Zhou S, Yang J, Wright AC, Foley M, Arthur JS, Whitehead KJ, Awad IA, Li DY, Zheng X, Kahn ML. Zhou Z, et al. Among authors: goddard lm. Nature. 2016 Apr 7;532(7597):122-6. doi: 10.1038/nature17178. Epub 2016 Mar 30. Nature. 2016. PMID: 27027284 Free PMC article.
Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation.
Tang AT, Sullivan KR, Hong CC, Goddard LM, Mahadevan A, Ren A, Pardo H, Peiper A, Griffin E, Tanes C, Mattei LM, Yang J, Li L, Mericko-Ishizuka P, Shen L, Hobson N, Girard R, Lightle R, Moore T, Shenkar R, Polster SP, Rödel CJ, Li N, Zhu Q, Whitehead KJ, Zheng X, Akers A, Morrison L, Kim H, Bittinger K, Lengner CJ, Schwaninger M, Velcich A, Augenlicht L, Abdelilah-Seyfried S, Min W, Marchuk DA, Awad IA, Kahn ML. Tang AT, et al. Among authors: goddard lm. Sci Transl Med. 2019 Nov 27;11(520):eaaw3521. doi: 10.1126/scitranslmed.aaw3521. Sci Transl Med. 2019. PMID: 31776290 Free PMC article.
Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican.
Hong CC, Tang AT, Detter MR, Choi JP, Wang R, Yang X, Guerrero AA, Wittig CF, Hobson N, Girard R, Lightle R, Moore T, Shenkar R, Polster SP, Goddard LM, Ren AA, Leu NA, Sterling S, Yang J, Li L, Chen M, Mericko-Ishizuka P, Dow LE, Watanabe H, Schwaninger M, Min W, Marchuk DA, Zheng X, Awad IA, Kahn ML. Hong CC, et al. Among authors: goddard lm. J Exp Med. 2020 Oct 5;217(10):e20200140. doi: 10.1084/jem.20200140. J Exp Med. 2020. PMID: 32648916 Free PMC article.
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