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SLC26A9 is selected for endoplasmic reticulum associated degradation (ERAD) via Hsp70-dependent targeting of the soluble STAS domain.
Biochem J. 2021 Dec 22;478(24):4203-4220. doi: 10.1042/BCJ20210644.
Biochem J. 2021.
PMID: 34821356
Free PMC article.
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Chung WJ, Goeckeler-Fried JL, Havasi V, Chiang A, Rowe SM, Plyler ZE, Hong JS, Mazur M, Piazza GA, Keeton AB, White EL, Rasmussen L, Weissman AM, Denny RA, Brodsky JL, Sorscher EJ.
Chung WJ, et al. Among authors: goeckeler fried jl.
PLoS One. 2016 Oct 12;11(10):e0163615. doi: 10.1371/journal.pone.0163615. eCollection 2016.
PLoS One. 2016.
PMID: 27732613
Free PMC article.
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Synthesis and evaluation of esterified Hsp70 agonists in cellular models of protein aggregation and folding.
Chiang AN, Liang M, Dominguez-Meijide A, Masaracchia C, Goeckeler-Fried JL, Mazzone CS, Newhouse DW, Kendsersky NM, Yates ME, Manos-Turvey A, Needham PG, Outeiro TF, Wipf P, Brodsky JL.
Chiang AN, et al. Among authors: goeckeler fried jl.
Bioorg Med Chem. 2019 Jan 1;27(1):79-91. doi: 10.1016/j.bmc.2018.11.011. Epub 2018 Nov 15.
Bioorg Med Chem. 2019.
PMID: 30528127
Free PMC article.
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Improved correction of F508del-CFTR biogenesis with a folding facilitator and an inhibitor of protein ubiquitination.
Goeckeler-Fried JL, Aldrin Denny R, Joshi D, Hill C, Larsen MB, Chiang AN, Frizzell RA, Wipf P, Sorscher EJ, Brodsky JL.
Goeckeler-Fried JL, et al.
Bioorg Med Chem Lett. 2021 Sep 15;48:128243. doi: 10.1016/j.bmcl.2021.128243. Epub 2021 Jul 8.
Bioorg Med Chem Lett. 2021.
PMID: 34246753
Free PMC article.
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Structural Basis for the Inhibitory Effects of Ubistatins in the Ubiquitin-Proteasome Pathway.
Nakasone MA, Lewis TA, Walker O, Thakur A, Mansour W, Castañeda CA, Goeckeler-Fried JL, Parlati F, Chou TF, Hayat O, Zhang D, Camara CM, Bonn SM, Nowicka UK, Krueger S, Glickman MH, Brodsky JL, Deshaies RJ, Fushman D.
Nakasone MA, et al. Among authors: goeckeler fried jl.
Structure. 2017 Dec 5;25(12):1839-1855.e11. doi: 10.1016/j.str.2017.10.007. Epub 2017 Nov 16.
Structure. 2017.
PMID: 29153505
Free PMC article.
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