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Cilia-Associated Oxysterols Activate Smoothened.
Raleigh DR, Sever N, Choksi PK, Sigg MA, Hines KM, Thompson BM, Elnatan D, Jaishankar P, Bisignano P, Garcia-Gonzalo FR, Krup AL, Eberl M, Byrne EFX, Siebold C, Wong SY, Renslo AR, Grabe M, McDonald JG, Xu L, Beachy PA, Reiter JF. Raleigh DR, et al. Among authors: grabe m. Mol Cell. 2018 Oct 18;72(2):316-327.e5. doi: 10.1016/j.molcel.2018.08.034. Mol Cell. 2018. PMID: 30340023 Free PMC article.
Stochastic steps in secondary active sugar transport.
Adelman JL, Ghezzi C, Bisignano P, Loo DD, Choe S, Abramson J, Rosenberg JM, Wright EM, Grabe M. Adelman JL, et al. Among authors: grabe m. Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):E3960-6. doi: 10.1073/pnas.1525378113. Epub 2016 Jun 20. Proc Natl Acad Sci U S A. 2016. PMID: 27325773 Free PMC article.
Conformational transitions of the sodium-dependent sugar transporter, vSGLT.
Paz A, Claxton DP, Kumar JP, Kazmier K, Bisignano P, Sharma S, Nolte SA, Liwag TM, Nayak V, Wright EM, Grabe M, Mchaourab HS, Abramson J. Paz A, et al. Among authors: grabe m. Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):E2742-E2751. doi: 10.1073/pnas.1718451115. Epub 2018 Mar 5. Proc Natl Acad Sci U S A. 2018. PMID: 29507231 Free PMC article.
Inhibitor binding mode and allosteric regulation of Na+-glucose symporters.
Bisignano P, Ghezzi C, Jo H, Polizzi NF, Althoff T, Kalyanaraman C, Friemann R, Jacobson MP, Wright EM, Grabe M. Bisignano P, et al. Among authors: grabe m. Nat Commun. 2018 Dec 7;9(1):5245. doi: 10.1038/s41467-018-07700-1. Nat Commun. 2018. PMID: 30532032 Free PMC article.
A kinetic mechanism for enhanced selectivity of membrane transport.
Bisignano P, Lee MA, George A, Zuckerman DM, Grabe M, Rosenberg JM. Bisignano P, et al. Among authors: grabe m. PLoS Comput Biol. 2020 Jul 2;16(7):e1007789. doi: 10.1371/journal.pcbi.1007789. eCollection 2020 Jul. PLoS Comput Biol. 2020. PMID: 32614861 Free PMC article.
Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+ site.
Wahlgren WY, Dunevall E, North RA, Paz A, Scalise M, Bisignano P, Bengtsson-Palme J, Goyal P, Claesson E, Caing-Carlsson R, Andersson R, Beis K, Nilsson UJ, Farewell A, Pochini L, Indiveri C, Grabe M, Dobson RCJ, Abramson J, Ramaswamy S, Friemann R. Wahlgren WY, et al. Among authors: grabe m. Nat Commun. 2018 May 1;9(1):1753. doi: 10.1038/s41467-018-04045-7. Nat Commun. 2018. PMID: 29717135 Free PMC article.
Mitochondrial uncouplers induce proton leak by activating AAC and UCP1.
Bertholet AM, Natale AM, Bisignano P, Suzuki J, Fedorenko A, Hamilton J, Brustovetsky T, Kazak L, Garrity R, Chouchani ET, Brustovetsky N, Grabe M, Kirichok Y. Bertholet AM, et al. Among authors: grabe m. Nature. 2022 Jun;606(7912):180-187. doi: 10.1038/s41586-022-04747-5. Epub 2022 May 25. Nature. 2022. PMID: 35614225 Free PMC article.
Transmembrane helix hydrophobicity is an energetic barrier during the retrotranslocation of integral membrane ERAD substrates.
Guerriero CJ, Reutter KR, Augustine AA, Preston GM, Weiberth KF, Mackie TD, Cleveland-Rubeor HC, Bethel NP, Callenberg KM, Nakatsukasa K, Grabe M, Brodsky JL. Guerriero CJ, et al. Among authors: grabe m. Mol Biol Cell. 2017 Jul 15;28(15):2076-2090. doi: 10.1091/mbc.E17-03-0184. Epub 2017 May 24. Mol Biol Cell. 2017. PMID: 28539401 Free PMC article.
160 results