Grabowski DR[Author] - Search Results

Year	Number of Results
1992	1
1998	3
1999	1
2000	1
2001	4
2002	1
2003	2
2005	1
2006	2
2008	1
2009	2
2017	1
2020	1
2021	2
2022	1
2024	0

1

SAR insights into TET2 catalytic domain inhibition: Synthesis of 2-Hydroxy-4-Methylene-pentanedicarboxylates.

Tiwari AD, Guan Y, Grabowski DR, Maciejewski JP, Jha BK, Phillips JG. Tiwari AD, et al. Among authors: grabowski dr. Bioorg Med Chem. 2021 Jun 1;39:116141. doi: 10.1016/j.bmc.2021.116141. Epub 2021 Apr 20. Bioorg Med Chem. 2021. PMID: 33894507 Free PMC article.

2

Eltrombopag inhibits TET dioxygenase to contribute to hematopoietic stem cell expansion in aplastic anemia.

Guan Y, Hasipek M, Jiang D, Tiwari AD, Grabowski DR, Pagliuca S, Kongkiatkamon S, Patel B, Singh S, Parker Y, LaFramboise T, Lindner D, Sekeres MA, Mian OY, Saunthararajah Y, Maciejewski JP, Jha BK. Guan Y, et al. Among authors: grabowski dr. J Clin Invest. 2022 Feb 15;132(4):e149856. doi: 10.1172/JCI149856. J Clin Invest. 2022. PMID: 35085104 Free PMC article.

3

Inhibition of NF-kappaB and proteasome activity in tumors: can we improve the therapeutic potential of topoisomerase I and topoisomerase II poisons.

Ganapathi R, Vaziri SA, Tabata M, Takigawa N, Grabowski DR, Bukowski RM, Ganapathi MK. Ganapathi R, et al. Among authors: grabowski dr. Curr Pharm Des. 2002;8(22):1945-58. doi: 10.2174/1381612023393549. Curr Pharm Des. 2002. PMID: 12171521 Review.

4

A Therapeutic Strategy for Preferential Targeting of TET2 Mutant and TET-dioxygenase Deficient Cells in Myeloid Neoplasms.

Guan Y, Tiwari AD, Phillips JG, Hasipek M, Grabowski DR, Pagliuca S, Gopal P, Kerr CM, Adema V, Radivoyevitch T, Parker Y, Lindner DJ, Meggendorfer M, Abazeed M, Sekeres MA, Mian OY, Haferlach T, Maciejewski JP, Jha BK. Guan Y, et al. Among authors: grabowski dr. Blood Cancer Discov. 2021 Mar;2(2):146-161. doi: 10.1158/2643-3230.BCD-20-0173. Epub 2020 Dec 7. Blood Cancer Discov. 2021. PMID: 33681816 Free PMC article.

5

Topoisomerase II poisoning by ICRF-193.

Huang KC, Gao H, Yamasaki EF, Grabowski DR, Liu S, Shen LL, Chan KK, Ganapathi R, Snapka RM. Huang KC, et al. Among authors: grabowski dr. J Biol Chem. 2001 Nov 30;276(48):44488-94. doi: 10.1074/jbc.M104383200. Epub 2001 Sep 27. J Biol Chem. 2001. PMID: 11577077 Free article.

6

Roles of the C-terminal domains of topoisomerase IIα and topoisomerase IIβ in regulation of the decatenation checkpoint.

Kozuki T, Chikamori K, Surleac MD, Micluta MA, Petrescu AJ, Norris EJ, Elson P, Hoeltge GA, Grabowski DR, Porter ACG, Ganapathi RN, Ganapathi MK. Kozuki T, et al. Among authors: grabowski dr. Nucleic Acids Res. 2017 Jun 2;45(10):5995-6010. doi: 10.1093/nar/gkx325. Nucleic Acids Res. 2017. PMID: 28472494 Free PMC article.

7

Casein kinase I delta/epsilon phosphorylates topoisomerase IIalpha at serine-1106 and modulates DNA cleavage activity.

Grozav AG, Chikamori K, Kozuki T, Grabowski DR, Bukowski RM, Willard B, Kinter M, Andersen AH, Ganapathi R, Ganapathi MK. Grozav AG, et al. Among authors: grabowski dr. Nucleic Acids Res. 2009 Feb;37(2):382-92. doi: 10.1093/nar/gkn934. Epub 2008 Nov 29. Nucleic Acids Res. 2009. PMID: 19043076 Free PMC article.

8

Proteasome inhibition with bortezomib enhances activity of topoisomerase I-targeting drugs by NF-kappaB-independent mechanisms.

Takigawa N, Vaziri SA, Grabowski DR, Chikamori K, Rybicki LR, Bukowski RM, Ganapathi MK, Ganapathi R, Mekhail T. Takigawa N, et al. Among authors: grabowski dr. Anticancer Res. 2006 May-Jun;26(3A):1869-76. Anticancer Res. 2006. PMID: 16827119 Free article.

9

Inhibition of proteasome activity by bortezomib in renal cancer cells is p53 dependent and VHL independent.

Vaziri SA, Grabowski DR, Hill J, Rybicki LR, Burk R, Bukowski RM, Ganapathi MK, Ganapathi R. Vaziri SA, et al. Among authors: grabowski dr. Anticancer Res. 2009 Aug;29(8):2961-9. Anticancer Res. 2009. PMID: 19661301 Free PMC article.

10

Phosphorylation of serine 1106 in the catalytic domain of topoisomerase II alpha regulates enzymatic activity and drug sensitivity.

Chikamori K, Grabowski DR, Kinter M, Willard BB, Yadav S, Aebersold RH, Bukowski RM, Hickson ID, Andersen AH, Ganapathi R, Ganapathi MK. Chikamori K, et al. Among authors: grabowski dr. J Biol Chem. 2003 Apr 11;278(15):12696-702. doi: 10.1074/jbc.M300837200. Epub 2003 Feb 4. J Biol Chem. 2003. PMID: 12569090 Free article.

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