Graham IR - Search Results

1

RNAi-mediated knockdown of dystrophin expression in adult mice does not lead to overt muscular dystrophy pathology.

Ghahramani Seno MM, Graham IR, Athanasopoulos T, Trollet C, Pohlschmidt M, Crompton MR, Dickson G. Ghahramani Seno MM, et al. Among authors: graham ir. Hum Mol Genet. 2008 Sep 1;17(17):2622-32. doi: 10.1093/hmg/ddn162. Epub 2008 May 28. Hum Mol Genet. 2008. PMID: 18511456

2

Stable micro-dystrophin gene transfer using an integrating adeno-retroviral hybrid vector ameliorates the dystrophic pathology in mdx mouse muscle.

Roberts ML, Wells DJ, Graham IR, Fabb SA, Hill VJ, Duisit G, Yuasa K, Takeda S, Cosset FL, Dickson G. Roberts ML, et al. Among authors: graham ir. Hum Mol Genet. 2002 Jul 15;11(15):1719-30. doi: 10.1093/hmg/11.15.1719. Hum Mol Genet. 2002. PMID: 12095914

3

Codon and mRNA sequence optimization of microdystrophin transgenes improves expression and physiological outcome in dystrophic mdx mice following AAV2/8 gene transfer.

Foster H, Sharp PS, Athanasopoulos T, Trollet C, Graham IR, Foster K, Wells DJ, Dickson G. Foster H, et al. Among authors: graham ir. Mol Ther. 2008 Nov;16(11):1825-32. doi: 10.1038/mt.2008.186. Epub 2008 Sep 2. Mol Ther. 2008. PMID: 18766174 Free article.

4

Transcriptomic analysis of dystrophin RNAi knockdown reveals a central role for dystrophin in muscle differentiation and contractile apparatus organization.

Ghahramani Seno MM, Trollet C, Athanasopoulos T, Graham IR, Hu P, Dickson G. Ghahramani Seno MM, et al. Among authors: graham ir. BMC Genomics. 2010 Jun 1;11:345. doi: 10.1186/1471-2164-11-345. BMC Genomics. 2010. PMID: 20515474 Free PMC article.

5

Recombinant adeno-associated viral (rAAV) vectors as therapeutic tools for Duchenne muscular dystrophy (DMD).

Athanasopoulos T, Graham IR, Foster H, Dickson G. Athanasopoulos T, et al. Among authors: graham ir. Gene Ther. 2004 Oct;11 Suppl 1:S109-21. doi: 10.1038/sj.gt.3302379. Gene Ther. 2004. PMID: 15454965 Review.

6

Acute regression of advanced and retardation of early aortic atheroma in immunocompetent apolipoprotein-E (apoE) deficient mice by administration of a second generation [E1(-), E3(-), polymerase(-)] adenovirus vector expressing human apoE.

Harris JD, Graham IR, Schepelmann S, Stannard AK, Roberts ML, Hodges BL, Hill V, Amalfitano A, Hassall DG, Owen JS, Dickson G. Harris JD, et al. Among authors: graham ir. Hum Mol Genet. 2002 Jan 1;11(1):43-58. doi: 10.1093/hmg/11.1.43. Hum Mol Genet. 2002. PMID: 11772998

7

Gene repair and mutagenesis mediated by chimeric RNA-DNA oligonucleotides: chimeraplasty for gene therapy and conversion of single nucleotide polymorphisms (SNPs).

Graham IR, Dickson G. Graham IR, et al. Biochim Biophys Acta. 2002 May 21;1587(1):1-6. doi: 10.1016/s0925-4439(02)00068-6. Biochim Biophys Acta. 2002. PMID: 12009417 Free article. Review.

8

Towards a therapeutic inhibition of dystrophin exon 23 splicing in mdx mouse muscle induced by antisense oligoribonucleotides (splicomers): target sequence optimisation using oligonucleotide arrays.

Graham IR, Hill VJ, Manoharan M, Inamati GB, Dickson G. Graham IR, et al. J Gene Med. 2004 Oct;6(10):1149-58. doi: 10.1002/jgm.603. J Gene Med. 2004. PMID: 15386737

9

Adenovirus-based targeting in myoblasts is hampered by nonhomologous vector integration.

Isman O, Roberts ML, Morgan JE, Graham IR, Goldring K, Lawrence-Watt DJ, Lu QL, Dunckley MG, Porter AC, Partridge TA, Dickson G. Isman O, et al. Among authors: graham ir. Hum Gene Ther. 2008 Oct;19(10):1000-8. doi: 10.1089/hum.2008.063. Hum Gene Ther. 2008. PMID: 18788904

10

Design of phosphorodiamidate morpholino oligomers (PMOs) for the induction of exon skipping of the human DMD gene.

Popplewell LJ, Trollet C, Dickson G, Graham IR. Popplewell LJ, et al. Among authors: graham ir. Mol Ther. 2009 Mar;17(3):554-61. doi: 10.1038/mt.2008.287. Epub 2009 Jan 13. Mol Ther. 2009. PMID: 19142179 Free PMC article.

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