Grossman TH - Search Results

1

Fluorocycline TP-271 Is Potent against Complicated Community-Acquired Bacterial Pneumonia Pathogens.

Grossman TH, Fyfe C, O'Brien W, Hackel M, Minyard MB, Waites KB, Dubois J, Murphy TM, Slee AM, Weiss WJ, Sutcliffe JA. Grossman TH, et al. mSphere. 2017 Feb 22;2(1):e00004-17. doi: 10.1128/mSphere.00004-17. eCollection 2017 Jan-Feb. mSphere. 2017. PMID: 28251179 Free PMC article.

2

Antibacterial activity of eravacycline (TP-434), a novel fluorocycline, against hospital and community pathogens.

Sutcliffe JA, O'Brien W, Fyfe C, Grossman TH. Sutcliffe JA, et al. Among authors: grossman th. Antimicrob Agents Chemother. 2013 Nov;57(11):5548-58. doi: 10.1128/AAC.01288-13. Epub 2013 Aug 26. Antimicrob Agents Chemother. 2013. PMID: 23979750 Free PMC article.

3

Target- and resistance-based mechanistic studies with TP-434, a novel fluorocycline antibiotic.

Grossman TH, Starosta AL, Fyfe C, O'Brien W, Rothstein DM, Mikolajka A, Wilson DN, Sutcliffe JA. Grossman TH, et al. Antimicrob Agents Chemother. 2012 May;56(5):2559-64. doi: 10.1128/AAC.06187-11. Epub 2012 Feb 21. Antimicrob Agents Chemother. 2012. PMID: 22354310 Free PMC article.

4

Development and characterization of a Pseudomonas aeruginosa in vitro coupled transcription-translation assay system for evaluation of translation inhibitors.

Fyfe C, Sutcliffe JA, Grossman TH. Fyfe C, et al. Among authors: grossman th. J Microbiol Methods. 2012 Sep;90(3):256-61. doi: 10.1016/j.mimet.2012.05.018. Epub 2012 Jun 5. J Microbiol Methods. 2012. PMID: 22677604 Free PMC article.

5

Eravacycline (TP-434) is active in vitro against biofilms formed by uropathogenic Escherichia coli.

Grossman TH, O'Brien W, Kerstein KO, Sutcliffe JA. Grossman TH, et al. Antimicrob Agents Chemother. 2015 Apr;59(4):2446-9. doi: 10.1128/AAC.04967-14. Epub 2015 Jan 26. Antimicrob Agents Chemother. 2015. PMID: 25624334 Free PMC article.

6

Eravacycline (TP-434) is efficacious in animal models of infection.

Grossman TH, Murphy TM, Slee AM, Lofland D, Sutcliffe JA. Grossman TH, et al. Antimicrob Agents Chemother. 2015 May;59(5):2567-71. doi: 10.1128/AAC.04354-14. Epub 2015 Feb 17. Antimicrob Agents Chemother. 2015. PMID: 25691636 Free PMC article.

7

Erratum for Grossman et al., target- and resistance-based mechanistic studies with TP-434, a novel fluorocycline antibiotic.

Grossman TH, Starosta AL, Fyfe C, O'Brien W, Rothstein DM, Mikolajka A, Wilson DN, Sutcliffe JA. Grossman TH, et al. Antimicrob Agents Chemother. 2015 Sep;59(9):5870. doi: 10.1128/AAC.01551-15. Antimicrob Agents Chemother. 2015. PMID: 26276898 Free PMC article. No abstract available.

8

Resistance to Macrolide Antibiotics in Public Health Pathogens.

Fyfe C, Grossman TH, Kerstein K, Sutcliffe J. Fyfe C, et al. Among authors: grossman th. Cold Spring Harb Perspect Med. 2016 Oct 3;6(10):a025395. doi: 10.1101/cshperspect.a025395. Cold Spring Harb Perspect Med. 2016. PMID: 27527699 Free PMC article. Review.

9

Heterocyclyl Tetracyclines. 1. 7-Trifluoromethyl-8-Pyrrolidinyltetracyclines: Potent, Broad Spectrum Antibacterial Agents with Enhanced Activity against Pseudomonas aeruginosa.

Deng Y, Sun C, Hunt DK, Fyfe C, Chen CL, Grossman TH, Sutcliffe JA, Xiao XY. Deng Y, et al. Among authors: grossman th. J Med Chem. 2017 Mar 23;60(6):2498-2512. doi: 10.1021/acs.jmedchem.6b01903. Epub 2017 Mar 15. J Med Chem. 2017. PMID: 28248499

10

Heterocyclyl tetracyclines. 2. 7-Methoxy-8-pyrrolidinyltetracyclines: discovery of TP-2758, a potent, orally efficacious antimicrobial against Gram-negative pathogens.

Sun C, Deng Y, Hunt DK, Fyfe C, Chen CL, Clark RB, Grossman TH, Sutcliffe JA, Xiao XY. Sun C, et al. Among authors: grossman th. J Antibiot (Tokyo). 2018 Feb;71(2):287-297. doi: 10.1038/ja.2017.86. Epub 2017 Jul 26. J Antibiot (Tokyo). 2018. PMID: 28743974

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