Guiles JW - Search Results

1

Structure of PolC reveals unique DNA binding and fidelity determinants.

Evans RJ, Davies DR, Bullard JM, Christensen J, Green LS, Guiles JW, Pata JD, Ribble WK, Janjic N, Jarvis TC. Evans RJ, et al. Among authors: guiles jw. Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20695-700. doi: 10.1073/pnas.0809989106. Epub 2008 Dec 23. Proc Natl Acad Sci U S A. 2008. PMID: 19106298 Free PMC article.

2

Spectrum of activity and mode of action of REP3123, a new antibiotic to treat Clostridium difficile infections.

Critchley IA, Green LS, Young CL, Bullard JM, Evans RJ, Price M, Jarvis TC, Guiles JW, Janjic N, Ochsner UA. Critchley IA, et al. Among authors: guiles jw. J Antimicrob Chemother. 2009 May;63(5):954-63. doi: 10.1093/jac/dkp041. Epub 2009 Mar 3. J Antimicrob Chemother. 2009. PMID: 19258353

3

Quinazolin-2-ylamino-quinazolin-4-ols as novel non-nucleoside inhibitors of bacterial DNA polymerase III.

Guiles J, Sun X, Critchley IA, Ochsner U, Tregay M, Stone K, Bertino J, Green L, Sabin R, Dean F, Dallmann HG, McHenry CS, Janjic N. Guiles J, et al. Bioorg Med Chem Lett. 2009 Feb 1;19(3):800-2. doi: 10.1016/j.bmcl.2008.12.038. Epub 2008 Dec 13. Bioorg Med Chem Lett. 2009. PMID: 19109016

4

Development of 4H-pyridopyrimidines: a class of selective bacterial protein synthesis inhibitors.

Guiles JW, Toro A, Ochsner UA, Bullard JM. Guiles JW, et al. Org Med Chem Lett. 2012 Feb 16;2(1):5. doi: 10.1186/2191-2858-2-5. Org Med Chem Lett. 2012. PMID: 22373064 Free PMC article.

5

Antibacterial activity of REP8839, a new antibiotic for topical use.

Critchley IA, Young CL, Stone KC, Ochsner UA, Guiles J, Tarasow T, Janjic N. Critchley IA, et al. Antimicrob Agents Chemother. 2005 Oct;49(10):4247-52. doi: 10.1128/AAC.49.10.4247-4252.2005. Antimicrob Agents Chemother. 2005. PMID: 16189105 Free PMC article.

6

Discovery and analysis of 4H-pyridopyrimidines, a class of selective bacterial protein synthesis inhibitors.

Ribble W, Hill WE, Ochsner UA, Jarvis TC, Guiles JW, Janjic N, Bullard JM. Ribble W, et al. Among authors: guiles jw. Antimicrob Agents Chemother. 2010 Nov;54(11):4648-57. doi: 10.1128/AAC.00638-10. Epub 2010 Aug 9. Antimicrob Agents Chemother. 2010. PMID: 20696870 Free PMC article.

7

New agents for Clostridium difficile-associated disease.

Guiles J, Critchley I, Sun X. Guiles J, et al. Expert Opin Investig Drugs. 2008 Nov;17(11):1671-83. doi: 10.1517/13543784.17.11.1671. Expert Opin Investig Drugs. 2008. PMID: 18922104 Review.

8

Grignard cross-coupling amenable to large scale production of alpha-fluorostyryl and alpha-fluorovinylthiophenes.

Qiu J, Gyorokos A, Tarasow TM, Guiles J. Qiu J, et al. J Org Chem. 2008 Dec 19;73(24):9775-7. doi: 10.1021/jo801647x. J Org Chem. 2008. PMID: 18980327

9

Novel inhibitors of potassium ion channels on human T lymphocytes.

Michne WF, Guiles JW, Treasurywala AM, Castonguay LA, Weigelt CA, Oconnor B, Volberg WA, Grant AM, Chadwick CC, Krafte DS, et al. Michne WF, et al. Among authors: guiles jw. J Med Chem. 1995 May 26;38(11):1877-83. doi: 10.1021/jm00011a007. J Med Chem. 1995. PMID: 7540207

10

Novel inhibitors of the nuclear factor of activated T cells (NFAT)-mediated transcription of beta-galactosidase: potential immunosuppressive and antiinflammatory agents.

Michne WF, Schroeder JD, Guiles JW, Treasurywala AM, Weigelt CA, Stansberry MF, McAvoy E, Shah CR, Baine Y, Sawutz DG, et al. Michne WF, et al. Among authors: guiles jw. J Med Chem. 1995 Jul 7;38(14):2557-69. doi: 10.1021/jm00014a009. J Med Chem. 1995. PMID: 7629796

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